BDBM50010389 CHEMBL3263965

SMILES: COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(ccc4F)-c4ccsc4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1

InChI Key: InChIKey=JGBFZYXPJYFPPR-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50010389   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50010389 (CHEMBL3263965) Show SMILES COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(ccc4F)-c4ccsc4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H34F2N4O5S2/c1-39-12-14-40(15-13-39)11-3-16-44-33-21-29-26(20-32(33)43-2)30(8-10-37-29)45-31-7-5-25(19-28(31)36)38-47(41,42)34-18-23(4-6-27(34)35)24-9-17-46-22-24/h4-10,17-22,38H,3,11-16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	572	n/a	n/a	n/a	n/a	n/a	n/a
Vichem Chemie Research Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant EGFR (unknown origin) using poly-GT peptide as substrate by Transcreener assay				ACS Med Chem Lett 5: 298-303 (2014) Article DOI: 10.1021/ml4003309 BindingDB Entry DOI: 10.7270/Q2HD7X6X
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50010389 (CHEMBL3263965) Show SMILES COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(ccc4F)-c4ccsc4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H34F2N4O5S2/c1-39-12-14-40(15-13-39)11-3-16-44-33-21-29-26(20-32(33)43-2)30(8-10-37-29)45-31-7-5-25(19-28(31)36)38-47(41,42)34-18-23(4-6-27(34)35)24-9-17-46-22-24/h4-10,17-22,38H,3,11-16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.18E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vichem Chemie Research Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant INSR (unknown origin) using fluorescent dye-labelled KKSRGDYMTMQIG peptide peptide as substrate after 1 hr by IMAP assay				ACS Med Chem Lett 5: 298-303 (2014) Article DOI: 10.1021/ml4003309 BindingDB Entry DOI: 10.7270/Q2HD7X6X
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50010389 (CHEMBL3263965) Show SMILES COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(ccc4F)-c4ccsc4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H34F2N4O5S2/c1-39-12-14-40(15-13-39)11-3-16-44-33-21-29-26(20-32(33)43-2)30(8-10-37-29)45-31-7-5-25(19-28(31)36)38-47(41,42)34-18-23(4-6-27(34)35)24-9-17-46-22-24/h4-10,17-22,38H,3,11-16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vichem Chemie Research Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant c-MET (unknown origin) using poly-AEKY peptide as substrate after 60 mins by ADPGlo assay				ACS Med Chem Lett 5: 298-303 (2014) Article DOI: 10.1021/ml4003309 BindingDB Entry DOI: 10.7270/Q2HD7X6X
					More data for this Ligand-Target Pair