BDBM50011234 CHEMBL3260330

SMILES: C1CC(CCO1)n1ccc(Nc2ncc3n(nnc3n2)-c2ccc3cn[nH]c3c2)n1

InChI Key: InChIKey=BWNLUTKKCVJOHI-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50011234   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 2-alpha kinase 4 (Homo sapiens (Human))	BDBM50011234 (CHEMBL3260330) Show SMILES C1CC(CCO1)n1ccc(Nc2ncc3n(nnc3n2)-c2ccc3cn[nH]c3c2)n1 Show InChI InChI=1S/C19H18N10O/c1-2-14(9-15-12(1)10-21-24-15)29-16-11-20-19(23-18(16)25-27-29)22-17-3-6-28(26-17)13-4-7-30-8-5-13/h1-3,6,9-11,13H,4-5,7-8H2,(H,21,24)(H,20,22,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Inhibition of GCN2 (unknown origin) using GFP-elF2a as substrate preincubated with substrate for 20 mins measured after 90 mins by Lanthascreen assay				ACS Med Chem Lett 5: 282-3 (2014) Article DOI: 10.1021/ml500052f BindingDB Entry DOI: 10.7270/Q2SQ91XX
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4 (Homo sapiens (Human))	BDBM50011234 (CHEMBL3260330) Show SMILES C1CC(CCO1)n1ccc(Nc2ncc3n(nnc3n2)-c2ccc3cn[nH]c3c2)n1 Show InChI InChI=1S/C19H18N10O/c1-2-14(9-15-12(1)10-21-24-15)29-16-11-20-19(23-18(16)25-27-29)22-17-3-6-28(26-17)13-4-7-30-8-5-13/h1-3,6,9-11,13H,4-5,7-8H2,(H,21,24)(H,20,22,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Inhibition of GCN2-mediated elF2alpha phosphorylation in human U2OS cells after 2 hrs by immunocytochemistry				ACS Med Chem Lett 5: 282-3 (2014) Article DOI: 10.1021/ml500052f BindingDB Entry DOI: 10.7270/Q2SQ91XX
					More data for this Ligand-Target Pair