BindingDB PrimarySearch

BDBM50011236 CHEMBL344314::Isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide::Isoquinolinesulfonamide, H-9::N-(2-aminoethyl)isoquinoline-5-sulfonamide

SMILES: NCCNS(=O)(=O)c1cccc2cnccc12

InChI Key: InChIKey=DCVZSHVZGVWQKV-UHFFFAOYSA-N

Data: 8 IC50

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50011236
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Casein kinase I isoform alpha (Homo sapiens (Human))	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.10E+5	n/a	n/a	n/a	n/a	7.4	30
Nagoya University School of Medicine					Assay Description Casein kinase activities were determined under the conditions as described by Huang et al (1982).				J Biol Chem 264: 4924-7 (1989) BindingDB Entry DOI: 10.7270/Q2K072VK
Nagoya University School of Medicine					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	7.4	30
Nagoya University School of Medicine					Assay Description Casein kinase activities were determined under the conditions as described by Huang et al (1982).				J Biol Chem 264: 4924-7 (1989) BindingDB Entry DOI: 10.7270/Q2K072VK
Nagoya University School of Medicine					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	7.4	30
Nagoya University School of Medicine					Assay Description Casein kinase activities were determined under the conditions as described by Huang et al (1982).				J Biol Chem 264: 4924-7 (1989) BindingDB Entry DOI: 10.7270/Q2K072VK
Nagoya University School of Medicine					More data for this Ligand-Target Pair
Protein kinase C (PKC) (Homo sapiens (Human))	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
URA CNRS 1309 Curated by ChEMBL					Assay Description Inhibition of protein kinase C (PKC)				J Med Chem 34: 73-8 (1991) BindingDB Entry DOI: 10.7270/Q2J38VS9
URA CNRS 1309 Curated by ChEMBL					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase II (Bos taurus (Bovine))	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	5.80E+4	n/a	n/a	n/a	n/a	7.4	30
Nagoya University School of Medicine					Assay Description Casein kinase activities were determined under the conditions as described by Huang et al (1982).				J Biol Chem 264: 4924-7 (1989) BindingDB Entry DOI: 10.7270/Q2K072VK
Nagoya University School of Medicine					More data for this Ligand-Target Pair
Protein kinase Pfmrk (Plasmodium falciparum)	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Research Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum Pfmrk				Bioorg Med Chem Lett 17: 4961-6 (2007) Article DOI: 10.1016/j.bmcl.2007.06.032 BindingDB Entry DOI: 10.7270/Q2GX4CC8
Institute of Research Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-dependent protein kinase (PKA) (Homo sapiens (Human))	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
URA CNRS 1309 Curated by ChEMBL					Assay Description Inhibition of cAMP-dependent protein kinase (PKA).				J Med Chem 34: 73-8 (1991) BindingDB Entry DOI: 10.7270/Q2J38VS9
URA CNRS 1309 Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-dependent protein kinase type I-alpha regulatory subunit (Bos taurus)	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	7.4	30
Nagoya University School of Medicine					Assay Description Casein kinase activities were determined under the conditions as described by Huang et al (1982).				J Biol Chem 264: 4924-7 (1989) BindingDB Entry DOI: 10.7270/Q2K072VK
Nagoya University School of Medicine					More data for this Ligand-Target Pair