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BDBM50011603 1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-2-yl]-prop-2-ynyl}-3-phenyl-1,3-dihydro-benzoimidazol-2-one::CHEMBL281779

SMILES: Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2n(-c2ccccc2)c1=O)c1ccccc1Cl

InChI Key: InChIKey=UJCMEXWIPFPQJP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50011603   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011603
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2n(-c2ccccc2)c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C31H21ClN6OS/c1-20-34-35-28-19-33-29(23-13-5-6-14-25(23)32)24-18-22(40-30(24)37(20)28)12-9-17-36-26-15-7-8-16-27(26)38(31(36)39)21-10-3-2-4-11-21/h2-8,10-11,13-16,18H,17,19H2,1H3
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n/an/a 1n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay


J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair