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SMILES: Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)COc2ccccc12)c1ccccc1Cl

InChI Key: InChIKey=UZNFEWAQORTTAF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50011634   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011634
PNG
(4-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)COc2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C26H18ClN5O2S/c1-16-29-30-23-14-28-25(18-8-2-3-9-20(18)27)19-13-17(35-26(19)32(16)23)7-6-12-31-21-10-4-5-11-22(21)34-15-24(31)33/h2-5,8-11,13H,12,14-15H2,1H3
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n/an/a 0.700n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair