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SMILES: Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)C2(C)CCCc3cccc1c23)c1ccccc1Cl

InChI Key: InChIKey=LWZNSCJSXYKWAF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50011676   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011676
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)C2(C)CCCc3cccc1c23)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C30H24ClN5OS/c1-18-33-34-25-17-32-27(21-11-3-4-12-23(21)31)22-16-20(38-28(22)36(18)25)10-7-15-35-24-13-5-8-19-9-6-14-30(2,26(19)24)29(35)37/h3-5,8,11-13,16H,6,9,14-15,17H2,1-2H3
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n/an/a 12n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair