BDBM50011760 1-(4-Amino-phenyl)-3-aza-bicyclo[3.1.0]hexane-2,4-dione::CHEMBL287574::US10849982, Compd # 4
SMILES: Nc1ccc(cc1)C12CC1C(=O)NC2=O
InChI Key: InChIKey=SGGCPUGLXWOPAP-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Cytochrome P450 19A1 (Homo sapiens (Human)) | BDBM50011760 (1-(4-Amino-phenyl)-3-aza-bicyclo[3.1.0]hexane-2,4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of human placental cytochrome P450 19A1 androstenedione | J Med Chem 31: 971-6 (1988) BindingDB Entry DOI: 10.7270/Q2154J7X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CRBN-DDB1 (Homo sapiens (Human)) | BDBM50011760 (1-(4-Amino-phenyl)-3-aza-bicyclo[3.1.0]hexane-2,4-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a |
C4 Therapeutics, Inc. US Patent | Assay Description Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP... | US Patent US10849982 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 19A1 (Homo sapiens (Human)) | BDBM50011760 (1-(4-Amino-phenyl)-3-aza-bicyclo[3.1.0]hexane-2,4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY AG. Curated by ChEMBL | Assay Description In vitro inhibition of human placental Cytochrome P450 19A1 aromatase | J Med Chem 34: 1329-34 (1991) BindingDB Entry DOI: 10.7270/Q2QN65RW | |||||||||||
More data for this Ligand-Target Pair |