new BindingDB logo
myBDB logout

BDBM50011852 4-(2-Chloro-phenyl)-2-(2-indan-5-yl-ethyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene::CHEMBL289463

SMILES: Cc1nnc2CN=C(c3cc(CCc4ccc5CCCc5c4)sc3-n12)c1ccccc1Cl

InChI Key: InChIKey=PVLUPPBGGLSUDG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50011852   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011852
PNG
(4-(2-Chloro-phenyl)-2-(2-indan-5-yl-ethyl)-9-methy...)
Show SMILES Cc1nnc2CN=C(c3cc(CCc4ccc5CCCc5c4)sc3-n12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C26H23ClN4S/c1-16-29-30-24-15-28-25(21-7-2-3-8-23(21)27)22-14-20(32-26(22)31(16)24)12-10-17-9-11-18-5-4-6-19(18)13-17/h2-3,7-9,11,13-14H,4-6,10,12,15H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 20n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair