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SMILES: Cc1nnc2CN=C(c3cc(sc3-n12)C#Cc1ccccn1)c1ccccc1Cl

InChI Key: InChIKey=NTXIFGGWEOLGTP-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50011883   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011883
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-pyridin-2-ylethynyl...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#Cc1ccccn1)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C22H14ClN5S/c1-14-26-27-20-13-25-21(17-7-2-3-8-19(17)23)18-12-16(29-22(18)28(14)20)10-9-15-6-4-5-11-24-15/h2-8,11-12H,13H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.

J Med Chem 34: 1440-6 (1991)


BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair