BDBM50012434 (REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hexan-1-ol::1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hexan-1-ol::1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hexan-1-ol (RG 5901)::1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hexan-1-ol(REV-5901)::CHEMBL8747::REV-5901::REV-901

SMILES: CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1

InChI Key: InChIKey=JRLOEMCOOZSCQP-UHFFFAOYSA-N

Data: 3 KI  14 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50012434   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cysteinyl leukotriene receptor 1 (GUINEA PIG)	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rorer Central Research Curated by ChEMBL					Assay Description Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)				J Med Chem 33: 1186-94 (1990) BindingDB Entry DOI: 10.7270/Q2TB15WM
					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1 (GUINEA PIG)	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for the inhibition of [3H]-leukotriene D4 binding to LTD4 receptor in guinea pig lung membranes				Bioorg Med Chem Lett 5: 1371-1376 (1995) Article DOI: 10.1016/0960-894X(95)00226-J BindingDB Entry DOI: 10.7270/Q2QR4X29
					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1 (GUINEA PIG)	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [3H]-LTD4 binding to LTD4 receptor in guinea pig lung membranes				Bioorg Med Chem Lett 5: 1365-1370 (1995) Article DOI: 10.1016/0960-894X(95)00225-I BindingDB Entry DOI: 10.7270/Q2VH5NSM
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Laboratories Curated by ChEMBL					Assay Description Ability to inhibit 5-lipoxygenase in guinea pig				J Med Chem 30: 2087-93 (1987) BindingDB Entry DOI: 10.7270/Q2FQ9VMQ
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to inhibit Lipoxygenase in vitro was determined				J Med Chem 30: 400-5 (1987) BindingDB Entry DOI: 10.7270/Q2K936JS
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>100	n/a	n/a	n/a	n/a
ICI Pharma Curated by ChEMBL					Assay Description Ex vivo inhibition of LTB4 production was measured in dog blood				J Med Chem 34: 1028-36 (1991) BindingDB Entry DOI: 10.7270/Q28G8MXH
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of 5-Lipoxygenase (5-LO) in rat basophilic leukemic cells				Bioorg Med Chem Lett 5: 1365-1370 (1995) Article DOI: 10.1016/0960-894X(95)00225-I BindingDB Entry DOI: 10.7270/Q2VH5NSM
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>4.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its in vitro inhibitory activity against RBL-1 5-LO (insuluble above 45 uM)				J Med Chem 30: 574-80 (1987) BindingDB Entry DOI: 10.7270/Q2QN67BB
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>4.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory activity against 5-lipoxygenase from rat basophilic leukemia cells.				J Med Chem 30: 1177-86 (1987) BindingDB Entry DOI: 10.7270/Q25M668Q
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description The compound was tested for inhibitory activity against 5-lipoxygenase in rat polymorphonuclear leukocytes[PMNS] (in vivo)				J Med Chem 35: 2501-24 (1992) BindingDB Entry DOI: 10.7270/Q23B60R4
					More data for this Ligand-Target Pair
Cyclooxygenase (Homo sapiens (Human))	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Laboratories Curated by ChEMBL					Assay Description Ability to inhibit Prostaglandin G/H synthase in guinea pig				J Med Chem 30: 2087-93 (1987) BindingDB Entry DOI: 10.7270/Q2FQ9VMQ
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharma Curated by ChEMBL					Assay Description In vitro inhibition of LTB4 production was measured in rat blood				J Med Chem 34: 1028-36 (1991) BindingDB Entry DOI: 10.7270/Q28G8MXH
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of rat neutrophil 5- Lipoxygenase (5-LO)				J Med Chem 30: 96-104 (1987) BindingDB Entry DOI: 10.7270/Q2PV6MKS
					More data for this Ligand-Target Pair
Cyclooxygenase (RAT)	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharma Curated by ChEMBL					Assay Description In vitro inhibition of PGE-2 production was measured in rat blood				J Med Chem 34: 1028-36 (1991) BindingDB Entry DOI: 10.7270/Q28G8MXH
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of rat polymorphonuclear leukocyte (PMN) 5-Lipoxygenase in vitro				J Med Chem 29: 1429-35 (1986) BindingDB Entry DOI: 10.7270/Q2GX49K4
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rorer Central Research Curated by ChEMBL					Assay Description Inhibition against 5-lipoxygenase from guinea pig polymorphonuclear lymphocytes				J Med Chem 33: 1186-94 (1990) BindingDB Entry DOI: 10.7270/Q2TB15WM
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>4.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of 5-lipoxygenase (5-lo) from the 20000 g supernatant of RBI-1 cells				J Med Chem 34: 2158-65 (1991) BindingDB Entry DOI: 10.7270/Q2NS0SWM
					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor (Homo sapiens (Human))	BDBM50012434 ((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...) Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase II				J Med Chem 35: 3832-44 (1992) BindingDB Entry DOI: 10.7270/Q2TQ625N
					More data for this Ligand-Target Pair