BDBM50012594 CHEMBL3260811

SMILES: OC(=O)c1nc(-c2ccccc2)n(c1-c1cccc(Cl)c1)-c1cccc(Cl)c1F

InChI Key: InChIKey=BWKUHDIFHWGKSW-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50012594   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50012594 (CHEMBL3260811) Show SMILES OC(=O)c1nc(-c2ccccc2)n(c1-c1cccc(Cl)c1)-c1cccc(Cl)c1F |(41.13,-1.76,;40.46,-3.15,;38.92,-3.25,;41.32,-4.43,;42.86,-4.48,;43.29,-5.96,;44.73,-6.49,;44.99,-8.01,;46.44,-8.54,;47.62,-7.55,;47.35,-6.03,;45.91,-5.5,;42.01,-6.82,;40.8,-5.87,;39.26,-5.87,;38.49,-7.19,;36.95,-7.19,;36.18,-5.85,;36.96,-4.52,;36.19,-3.18,;38.5,-4.53,;41.95,-8.36,;40.59,-9.08,;40.53,-10.61,;41.84,-11.43,;43.21,-10.7,;44.51,-11.52,;43.26,-9.17,;44.61,-8.44,)| Show InChI InChI=1S/C22H13Cl2FN2O2/c23-15-9-4-8-14(12-15)20-19(22(28)29)26-21(13-6-2-1-3-7-13)27(20)17-11-5-10-16(24)18(17)25/h1-12H,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) (2 to 188) assessed as inhibition of p53-MDM2 interaction by TR-FRET assay				Bioorg Med Chem Lett 24: 2110-4 (2014) Article DOI: 10.1016/j.bmcl.2014.03.039 BindingDB Entry DOI: 10.7270/Q2RJ4M1C
					More data for this Ligand-Target Pair