BDBM50013163 CHEMBL3262358

SMILES: N[C@H]1CCCC[C@H]1Nc1cc2nc[nH]c(=O)c2c(Nc2cccc3c(Cl)c[nH]c23)n1

InChI Key: InChIKey=KDXHNAAPPFDXHV-UONOGXRCSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50013163   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50013163 (CHEMBL3262358) Show SMILES N[C@H]1CCCC[C@H]1Nc1cc2nc[nH]c(=O)c2c(Nc2cccc3c(Cl)c[nH]c23)n1 |r| Show InChI InChI=1S/C21H22ClN7O/c22-12-9-24-19-11(12)4-3-7-15(19)28-20-18-16(25-10-26-21(18)30)8-17(29-20)27-14-6-2-1-5-13(14)23/h3-4,7-10,13-14,24H,1-2,5-6,23H2,(H,25,26,30)(H2,27,28,29)/t13-,14+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of Syk in anti IgM-stimulated human Ramos cells assessed as BLNK phosphorylation by cellular assay				Bioorg Med Chem Lett 24: 2278-82 (2014) Article DOI: 10.1016/j.bmcl.2014.03.075 BindingDB Entry DOI: 10.7270/Q2PN976C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50013163 (CHEMBL3262358) Show SMILES N[C@H]1CCCC[C@H]1Nc1cc2nc[nH]c(=O)c2c(Nc2cccc3c(Cl)c[nH]c23)n1 |r| Show InChI InChI=1S/C21H22ClN7O/c22-12-9-24-19-11(12)4-3-7-15(19)28-20-18-16(25-10-26-21(18)30)8-17(29-20)27-14-6-2-1-5-13(14)23/h3-4,7-10,13-14,24H,1-2,5-6,23H2,(H,25,26,30)(H2,27,28,29)/t13-,14+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of Syk (unknown origin) using 4 uM peptide assessed as product formation after 60 mins incubation by microfluidic mobility shift assay				Bioorg Med Chem Lett 24: 2278-82 (2014) Article DOI: 10.1016/j.bmcl.2014.03.075 BindingDB Entry DOI: 10.7270/Q2PN976C
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50013163 (CHEMBL3262358) Show SMILES N[C@H]1CCCC[C@H]1Nc1cc2nc[nH]c(=O)c2c(Nc2cccc3c(Cl)c[nH]c23)n1 |r| Show InChI InChI=1S/C21H22ClN7O/c22-12-9-24-19-11(12)4-3-7-15(19)28-20-18-16(25-10-26-21(18)30)8-17(29-20)27-14-6-2-1-5-13(14)23/h3-4,7-10,13-14,24H,1-2,5-6,23H2,(H,25,26,30)(H2,27,28,29)/t13-,14+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human ERG by Q-patch assay				Bioorg Med Chem Lett 24: 2278-82 (2014) Article DOI: 10.1016/j.bmcl.2014.03.075 BindingDB Entry DOI: 10.7270/Q2PN976C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM50013163 (CHEMBL3262358) Show SMILES N[C@H]1CCCC[C@H]1Nc1cc2nc[nH]c(=O)c2c(Nc2cccc3c(Cl)c[nH]c23)n1 |r| Show InChI InChI=1S/C21H22ClN7O/c22-12-9-24-19-11(12)4-3-7-15(19)28-20-18-16(25-10-26-21(18)30)8-17(29-20)27-14-6-2-1-5-13(14)23/h3-4,7-10,13-14,24H,1-2,5-6,23H2,(H,25,26,30)(H2,27,28,29)/t13-,14+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	815	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of ZAP70 (unknown origin)				Bioorg Med Chem Lett 24: 2278-82 (2014) Article DOI: 10.1016/j.bmcl.2014.03.075 BindingDB Entry DOI: 10.7270/Q2PN976C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50013163 (CHEMBL3262358) Show SMILES N[C@H]1CCCC[C@H]1Nc1cc2nc[nH]c(=O)c2c(Nc2cccc3c(Cl)c[nH]c23)n1 |r| Show InChI InChI=1S/C21H22ClN7O/c22-12-9-24-19-11(12)4-3-7-15(19)28-20-18-16(25-10-26-21(18)30)8-17(29-20)27-14-6-2-1-5-13(14)23/h3-4,7-10,13-14,24H,1-2,5-6,23H2,(H,25,26,30)(H2,27,28,29)/t13-,14+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.81E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 24: 2278-82 (2014) Article DOI: 10.1016/j.bmcl.2014.03.075 BindingDB Entry DOI: 10.7270/Q2PN976C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM50013163 (CHEMBL3262358) Show SMILES N[C@H]1CCCC[C@H]1Nc1cc2nc[nH]c(=O)c2c(Nc2cccc3c(Cl)c[nH]c23)n1 |r| Show InChI InChI=1S/C21H22ClN7O/c22-12-9-24-19-11(12)4-3-7-15(19)28-20-18-16(25-10-26-21(18)30)8-17(29-20)27-14-6-2-1-5-13(14)23/h3-4,7-10,13-14,24H,1-2,5-6,23H2,(H,25,26,30)(H2,27,28,29)/t13-,14+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of Lyn (unknown origin)				Bioorg Med Chem Lett 24: 2278-82 (2014) Article DOI: 10.1016/j.bmcl.2014.03.075 BindingDB Entry DOI: 10.7270/Q2PN976C
					More data for this Ligand-Target Pair