Found 12 hits for monomerid = 50013172 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50013172
(CHEMBL3262624)Show SMILES N[C@H]1COCC[C@H]1Nc1cc2cc[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 |r| Show InChI InChI=1S/C21H22N6O2/c22-14-11-29-9-6-15(14)25-17-10-13-5-8-24-21(28)18(13)20(27-17)26-16-3-1-2-12-4-7-23-19(12)16/h1-5,7-8,10,14-15,23H,6,9,11,22H2,(H,24,28)(H2,25,26,27)/t14-,15+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of Syk in anti IgM-stimulated human Ramos cells assessed as BLNK phosphorylation by cellular assay |
Bioorg Med Chem Lett 24: 2278-82 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.075
BindingDB Entry DOI: 10.7270/Q2PN976C |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50013172
(CHEMBL3262624)Show SMILES N[C@H]1COCC[C@H]1Nc1cc2cc[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 |r| Show InChI InChI=1S/C21H22N6O2/c22-14-11-29-9-6-15(14)25-17-10-13-5-8-24-21(28)18(13)20(27-17)26-16-3-1-2-12-4-7-23-19(12)16/h1-5,7-8,10,14-15,23H,6,9,11,22H2,(H,24,28)(H2,25,26,27)/t14-,15+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 433 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of Syk in human whole blood assessed as inhibition of P-SLP76 in CD14+ monocytes by flow cytometry |
Bioorg Med Chem Lett 24: 2278-82 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.075
BindingDB Entry DOI: 10.7270/Q2PN976C |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50013172
(CHEMBL3262624)Show SMILES N[C@H]1COCC[C@H]1Nc1cc2cc[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 |r| Show InChI InChI=1S/C21H22N6O2/c22-14-11-29-9-6-15(14)25-17-10-13-5-8-24-21(28)18(13)20(27-17)26-16-3-1-2-12-4-7-23-19(12)16/h1-5,7-8,10,14-15,23H,6,9,11,22H2,(H,24,28)(H2,25,26,27)/t14-,15+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of Syk (unknown origin) using 4 uM peptide assessed as product formation after 60 mins incubation by microfluidic mobility shift assay |
Bioorg Med Chem Lett 24: 2278-82 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.075
BindingDB Entry DOI: 10.7270/Q2PN976C |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lyn
(Homo sapiens (Human)) | BDBM50013172
(CHEMBL3262624)Show SMILES N[C@H]1COCC[C@H]1Nc1cc2cc[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 |r| Show InChI InChI=1S/C21H22N6O2/c22-14-11-29-9-6-15(14)25-17-10-13-5-8-24-21(28)18(13)20(27-17)26-16-3-1-2-12-4-7-23-19(12)16/h1-5,7-8,10,14-15,23H,6,9,11,22H2,(H,24,28)(H2,25,26,27)/t14-,15+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of Lyn (unknown origin) |
Bioorg Med Chem Lett 24: 2278-82 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.075
BindingDB Entry DOI: 10.7270/Q2PN976C |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase ZAP-70
(Homo sapiens (Human)) | BDBM50013172
(CHEMBL3262624)Show SMILES N[C@H]1COCC[C@H]1Nc1cc2cc[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 |r| Show InChI InChI=1S/C21H22N6O2/c22-14-11-29-9-6-15(14)25-17-10-13-5-8-24-21(28)18(13)20(27-17)26-16-3-1-2-12-4-7-23-19(12)16/h1-5,7-8,10,14-15,23H,6,9,11,22H2,(H,24,28)(H2,25,26,27)/t14-,15+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of ZAP70 (unknown origin) |
Bioorg Med Chem Lett 24: 2278-82 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.075
BindingDB Entry DOI: 10.7270/Q2PN976C |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50013172
(CHEMBL3262624)Show SMILES N[C@H]1COCC[C@H]1Nc1cc2cc[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 |r| Show InChI InChI=1S/C21H22N6O2/c22-14-11-29-9-6-15(14)25-17-10-13-5-8-24-21(28)18(13)20(27-17)26-16-3-1-2-12-4-7-23-19(12)16/h1-5,7-8,10,14-15,23H,6,9,11,22H2,(H,24,28)(H2,25,26,27)/t14-,15+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay |
J Med Chem 58: 1950-63 (2015)
Article DOI: 10.1021/jm5018863
BindingDB Entry DOI: 10.7270/Q2G44S0C |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50013172
(CHEMBL3262624)Show SMILES N[C@H]1COCC[C@H]1Nc1cc2cc[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 |r| Show InChI InChI=1S/C21H22N6O2/c22-14-11-29-9-6-15(14)25-17-10-13-5-8-24-21(28)18(13)20(27-17)26-16-3-1-2-12-4-7-23-19(12)16/h1-5,7-8,10,14-15,23H,6,9,11,22H2,(H,24,28)(H2,25,26,27)/t14-,15+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.49E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of human ERG by Q-patch assay |
Bioorg Med Chem Lett 24: 2278-82 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.075
BindingDB Entry DOI: 10.7270/Q2PN976C |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50013172
(CHEMBL3262624)Show SMILES N[C@H]1COCC[C@H]1Nc1cc2cc[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 |r| Show InChI InChI=1S/C21H22N6O2/c22-14-11-29-9-6-15(14)25-17-10-13-5-8-24-21(28)18(13)20(27-17)26-16-3-1-2-12-4-7-23-19(12)16/h1-5,7-8,10,14-15,23H,6,9,11,22H2,(H,24,28)(H2,25,26,27)/t14-,15+/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of Flt3 (unknown origin) |
Bioorg Med Chem Lett 24: 2278-82 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.075
BindingDB Entry DOI: 10.7270/Q2PN976C |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50013172
(CHEMBL3262624)Show SMILES N[C@H]1COCC[C@H]1Nc1cc2cc[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 |r| Show InChI InChI=1S/C21H22N6O2/c22-14-11-29-9-6-15(14)25-17-10-13-5-8-24-21(28)18(13)20(27-17)26-16-3-1-2-12-4-7-23-19(12)16/h1-5,7-8,10,14-15,23H,6,9,11,22H2,(H,24,28)(H2,25,26,27)/t14-,15+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.49E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of human ERG expressed in CHO cells by automated Qpatch clamp assay |
J Med Chem 58: 1950-63 (2015)
Article DOI: 10.1021/jm5018863
BindingDB Entry DOI: 10.7270/Q2G44S0C |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50013172
(CHEMBL3262624)Show SMILES N[C@H]1COCC[C@H]1Nc1cc2cc[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 |r| Show InChI InChI=1S/C21H22N6O2/c22-14-11-29-9-6-15(14)25-17-10-13-5-8-24-21(28)18(13)20(27-17)26-16-3-1-2-12-4-7-23-19(12)16/h1-5,7-8,10,14-15,23H,6,9,11,22H2,(H,24,28)(H2,25,26,27)/t14-,15+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 433 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes assessed as phospho-SLP76 level preincubated for 30 mins followed by anti-CD32 stimul... |
J Med Chem 58: 1950-63 (2015)
Article DOI: 10.1021/jm5018863
BindingDB Entry DOI: 10.7270/Q2G44S0C |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50013172
(CHEMBL3262624)Show SMILES N[C@H]1COCC[C@H]1Nc1cc2cc[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 |r| Show InChI InChI=1S/C21H22N6O2/c22-14-11-29-9-6-15(14)25-17-10-13-5-8-24-21(28)18(13)20(27-17)26-16-3-1-2-12-4-7-23-19(12)16/h1-5,7-8,10,14-15,23H,6,9,11,22H2,(H,24,28)(H2,25,26,27)/t14-,15+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation... |
J Med Chem 58: 1950-63 (2015)
Article DOI: 10.1021/jm5018863
BindingDB Entry DOI: 10.7270/Q2G44S0C |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50013172
(CHEMBL3262624)Show SMILES N[C@H]1COCC[C@H]1Nc1cc2cc[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 |r| Show InChI InChI=1S/C21H22N6O2/c22-14-11-29-9-6-15(14)25-17-10-13-5-8-24-21(28)18(13)20(27-17)26-16-3-1-2-12-4-7-23-19(12)16/h1-5,7-8,10,14-15,23H,6,9,11,22H2,(H,24,28)(H2,25,26,27)/t14-,15+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of JAK2 (unknown origin) |
Bioorg Med Chem Lett 24: 2278-82 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.075
BindingDB Entry DOI: 10.7270/Q2PN976C |
More data for this
Ligand-Target Pair | |
Search and Browse
