Found 4 hits for monomerid = 50014413 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50014413
(CHEMBL3261161)Show SMILES OC[C@@H](O)Cn1ncc2cncc(Nc3ccc(I)cc3F)c2c1=O |r| Show InChI InChI=1S/C16H14FIN4O3/c17-12-3-10(18)1-2-13(12)21-14-6-19-4-9-5-20-22(7-11(24)8-23)16(25)15(9)14/h1-6,11,21,23-24H,7-8H2/t11-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of MEK1 in human COLO205 cells |
Bioorg Med Chem Lett 24: 2555-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.086
BindingDB Entry DOI: 10.7270/Q2PG1T73 |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50014413
(CHEMBL3261161)Show SMILES OC[C@@H](O)Cn1ncc2cncc(Nc3ccc(I)cc3F)c2c1=O |r| Show InChI InChI=1S/C16H14FIN4O3/c17-12-3-10(18)1-2-13(12)21-14-6-19-4-9-5-20-22(7-11(24)8-23)16(25)15(9)14/h1-6,11,21,23-24H,7-8H2/t11-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of MEK1 (unknown origin) |
Bioorg Med Chem Lett 24: 2555-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.086
BindingDB Entry DOI: 10.7270/Q2PG1T73 |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50014413
(CHEMBL3261161)Show SMILES OC[C@@H](O)Cn1ncc2cncc(Nc3ccc(I)cc3F)c2c1=O |r| Show InChI InChI=1S/C16H14FIN4O3/c17-12-3-10(18)1-2-13(12)21-14-6-19-4-9-5-20-22(7-11(24)8-23)16(25)15(9)14/h1-6,11,21,23-24H,7-8H2/t11-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of MEK1 in human A549 cells |
Bioorg Med Chem Lett 24: 2555-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.086
BindingDB Entry DOI: 10.7270/Q2PG1T73 |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50014413
(CHEMBL3261161)Show SMILES OC[C@@H](O)Cn1ncc2cncc(Nc3ccc(I)cc3F)c2c1=O |r| Show InChI InChI=1S/C16H14FIN4O3/c17-12-3-10(18)1-2-13(12)21-14-6-19-4-9-5-20-22(7-11(24)8-23)16(25)15(9)14/h1-6,11,21,23-24H,7-8H2/t11-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of MEK1 in human HCT116 cells |
Bioorg Med Chem Lett 24: 2555-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.086
BindingDB Entry DOI: 10.7270/Q2PG1T73 |
More data for this
Ligand-Target Pair | |
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