BDBM50015152 CHEMBL115468::N-hydroxy-1-naphthamide::Naphthalene-1-carboxylic acid hydroxyamide

SMILES: ONC(=O)c1cccc2ccccc12

InChI Key: InChIKey=JRZGPWOEHDOVMC-UHFFFAOYSA-N

Data: 7 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50015152   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50015152 (CHEMBL115468 | N-hydroxy-1-naphthamide | Naphthale...) Show SMILES ONC(=O)c1cccc2ccccc12 Show InChI InChI=1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)				J Med Chem 33: 992-8 (1990) BindingDB Entry DOI: 10.7270/Q2WW7GNM
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50015152 (CHEMBL115468 | N-hydroxy-1-naphthamide | Naphthale...) Show SMILES ONC(=O)c1cccc2ccccc12 Show InChI InChI=1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.				J Med Chem 45: 5628-39 (2002) BindingDB Entry DOI: 10.7270/Q20C4V3M
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50015152 (CHEMBL115468 | N-hydroxy-1-naphthamide | Naphthale...) Show SMILES ONC(=O)c1cccc2ccccc12 Show InChI InChI=1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Stromelysin (MMP-3)				J Med Chem 45: 5628-39 (2002) BindingDB Entry DOI: 10.7270/Q20C4V3M
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50015152 (CHEMBL115468 | N-hydroxy-1-naphthamide | Naphthale...) Show SMILES ONC(=O)c1cccc2ccccc12 Show InChI InChI=1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ithaca College Curated by ChEMBL					Assay Description Inhibition of human HDAC8 by [3H]acetyl histone peptide assay				Bioorg Med Chem Lett 17: 2874-8 (2007) Article DOI: 10.1016/j.bmcl.2007.02.064 BindingDB Entry DOI: 10.7270/Q2513XWG
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50015152 (CHEMBL115468 | N-hydroxy-1-naphthamide | Naphthale...) Show SMILES ONC(=O)c1cccc2ccccc12 Show InChI InChI=1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	4.27E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1)				J Med Chem 33: 992-8 (1990) BindingDB Entry DOI: 10.7270/Q2WW7GNM
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50015152 (CHEMBL115468 | N-hydroxy-1-naphthamide | Naphthale...) Show SMILES ONC(=O)c1cccc2ccccc12 Show InChI InChI=1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Ithaca College Curated by ChEMBL					Assay Description Inhibition of human HDAC1 by [3H]acetyl histone peptide assay				Bioorg Med Chem Lett 17: 2874-8 (2007) Article DOI: 10.1016/j.bmcl.2007.02.064 BindingDB Entry DOI: 10.7270/Q2513XWG
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50015152 (CHEMBL115468 | N-hydroxy-1-naphthamide | Naphthale...) Show SMILES ONC(=O)c1cccc2ccccc12 Show InChI InChI=1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory activity against RBL-1 5-LO				J Med Chem 30: 574-80 (1987) BindingDB Entry DOI: 10.7270/Q2QN67BB
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50015152 (CHEMBL115468 | N-hydroxy-1-naphthamide | Naphthale...) Show SMILES ONC(=O)c1cccc2ccccc12 Show InChI InChI=1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Dissociation constant for Matrix Metalloprotease-3 (MMP-3)				J Med Chem 47: 3463-82 (2004) Article DOI: 10.1021/jm040031v BindingDB Entry DOI: 10.7270/Q2NC61ZJ
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50015152 (CHEMBL115468 | N-hydroxy-1-naphthamide | Naphthale...) Show SMILES ONC(=O)c1cccc2ccccc12 Show InChI InChI=1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Ithaca College Curated by ChEMBL					Assay Description Inhibition of human HDAC6 by [3H]acetyl histone peptide assay				Bioorg Med Chem Lett 17: 2874-8 (2007) Article DOI: 10.1016/j.bmcl.2007.02.064 BindingDB Entry DOI: 10.7270/Q2513XWG
					More data for this Ligand-Target Pair