BDBM50015234 4,4''[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE::4-[6-(4-Carbamimidoyl-phenoxy)-hexyloxy]-benzamidine::4-{6-[4-amino(imino)methylphenoxy]hexyloxy}phenyl-iminomethanamine::4-{6-[4-ammino(imino)methylphenoxy]hexyloxy}phenyl-iminomethanammine::CHEMBL25105::Hexamidine::US9138393, Hexamidine diisethionate::US9144538, Hexamidine diisethionate
SMILES: NC(=N)c1ccc(OCCCCCCOc2ccc(cc2)C(N)=N)cc1
InChI Key: InChIKey=OQLKNTOKMBVBKV-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prothrombin (Homo sapiens (Human)) | BDBM50015234 (4,4''[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDA...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | 224 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description compound was tested for inhibitory activity against Thrombin | J Med Chem 44: 1349-55 (2001) BindingDB Entry DOI: 10.7270/Q2057F62 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matriptase (Homo sapiens (Human)) | BDBM50015234 (4,4''[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDA...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | 924 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description compound was tested for inhibitory activity against Matriptase | J Med Chem 44: 1349-55 (2001) BindingDB Entry DOI: 10.7270/Q2057F62 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trypsin-1 (Homo sapiens (Human)) | BDBM50015234 (4,4''[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDA...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description Inhibition of trypsin by amidase assay. | J Med Chem 33: 1252-7 (1990) BindingDB Entry DOI: 10.7270/Q2154HNW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Urokinase-type plasminogen activator (Homo sapiens (Human)) | BDBM50015234 (4,4''[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDA...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | 1.44E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description compound was tested for inhibitory activity against Urokinase-type plasminogen activator(microPa) | J Med Chem 44: 1349-55 (2001) BindingDB Entry DOI: 10.7270/Q2057F62 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50015234 (4,4''[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDA...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Procter & Gamble Company US Patent | Assay Description A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ... | US Patent US9138393 (2015) BindingDB Entry DOI: 10.7270/Q2GF0S8J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50015234 (4,4''[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDA...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Procter & Gamble Company US Patent | Assay Description Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ... | US Patent US9144538 (2015) BindingDB Entry DOI: 10.7270/Q22806DV | |||||||||||
More data for this Ligand-Target Pair |