BDBM50015296 CHEMBL3263076::US9120798, 13
SMILES: Cc1cc(-c2nnc(Nc3ccccc3N3CC4(CCN(CC(C)(C)C)CC4)c4c3c(O)ccc4Cl)s2)n(C)n1
InChI Key: InChIKey=QHBAYXBBRZABLL-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Purinergic receptor P2Y1 (Homo sapiens (Human)) | BDBM50015296 (CHEMBL3263076 | US9120798, 13) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Curated by ChEMBL | Assay Description Displacement of [33P]2-MeS-ADP from human cloned P2Y1 receptor expressed in HEK293 cells by SPA analysis | Bioorg Med Chem Lett 24: 2481-5 (2014) Article DOI: 10.1016/j.bmcl.2014.04.011 BindingDB Entry DOI: 10.7270/Q2R78GS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purinergic receptor P2Y1 (Homo sapiens (Human)) | BDBM50015296 (CHEMBL3263076 | US9120798, 13) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Curated by ChEMBL | Assay Description Inhibition of P2Y1 receptor in human washed platelets assessed as decrease in 2-methylthio-ADP-induced calcium signal transduction pathway activation... | Bioorg Med Chem Lett 24: 2481-5 (2014) Article DOI: 10.1016/j.bmcl.2014.04.011 BindingDB Entry DOI: 10.7270/Q2R78GS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purinergic receptor P2Y1 (Homo sapiens (Human)) | BDBM50015296 (CHEMBL3263076 | US9120798, 13) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description A membrane binding assay was used to identify inhibitors of [33P] 2MeS- ADP binding to cloned human P2Y1 receptors. The cDNA clone for human P2Yi was... | US Patent US9120798 (2015) BindingDB Entry DOI: 10.7270/Q2S75F47 | |||||||||||
More data for this Ligand-Target Pair |