BindingDB PrimarySearch

BDBM50015677 (S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester::1,2-Dioctanoyl glycerol::1,2-dioctanoyl-sn-glycerol::CHEMBL55267::Octanoic acid 1-hydroxymethyl-2-octanoyloxy-ethyl ester::Octanoic acid 1-hydroxymethyl-2-octanoyloxy-ethyl ester(diC8)

SMILES: CCCCCCCC(=O)OC[C@H](CO)OC(=O)CCCCCCC

InChI Key: InChIKey=ZQBULZYTDGUSSK-KRWDZBQOSA-N

Data: 9 KI 3 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50015677
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein kinase C delta type (Homo sapiens (Human))	BDBM50015677 ((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester \| 1,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	6.80	-10.9	n/a	n/a	n/a	n/a	n/a	7.4	18
National Institutes of Health					Assay Description [3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.				J Biol Chem 283: 10543-9 (2008) Article DOI: 10.1074/jbc.M707463200 BindingDB Entry DOI: 10.7270/Q2CF9NQ6
National Institutes of Health					More data for this Ligand-Target Pair
Protein kinase C eta (Mus musculus)	BDBM50015677 ((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester \| 1,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [3H]- PDBu binding to peptide D of mouse skin Protein kinase C eta				Bioorg Med Chem Lett 6: 353-356 (1996) Article DOI: 10.1016/0960-894X(96)00026-1 BindingDB Entry DOI: 10.7270/Q2NG4QMM
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Protein Kinase C, alpha (Bos taurus (bovine))	BDBM50015677 ((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester \| 1,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Ability to displace bound [20-3H]-PDBU from a recombinant single isozyme (PKCalpha) in the presence of phosphatidylserine				J Med Chem 44: 1892-904 (2001) BindingDB Entry DOI: 10.7270/Q2H995WH
National Cancer Institute at Frederick Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50015677 ((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester \| 1,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Displacement of [20-3H] phorbol 12,13-dibutyrate from protein kinase C alpha				Bioorg Med Chem Lett 10: 653-5 (2000) BindingDB Entry DOI: 10.7270/Q2G16011
National Cancer Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50015677 ((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester \| 1,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Helsinki Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from human recombinant PKCalpha expressed in Sf9 cells by liquid scintillation counting				J Med Chem 52: 3969-81 (2009) Article DOI: 10.1021/jm900229p BindingDB Entry DOI: 10.7270/Q2ZK5GJ1
University of Helsinki Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha (Homo sapiens (Human))	BDBM50015677 ((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester \| 1,...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	2.82E+3	-7.39	n/a	n/a	n/a	n/a	n/a	7.4	18
National Institutes of Health					Assay Description [3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.				J Biol Chem 283: 10543-9 (2008) Article DOI: 10.1074/jbc.M707463200 BindingDB Entry DOI: 10.7270/Q2CF9NQ6
National Institutes of Health					More data for this Ligand-Target Pair
Protein kinase C gamma (Rattus norvegicus)	BDBM50015677 ((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester \| 1,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article	2.93E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [3H]- PDBu binding to peptide C, rat brain PKC gamma				Bioorg Med Chem Lett 6: 353-356 (1996) Article DOI: 10.1016/0960-894X(96)00026-1 BindingDB Entry DOI: 10.7270/Q2NG4QMM
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50015677 ((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester \| 1,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	6.70E+3	-6.89	n/a	n/a	n/a	n/a	n/a	7.4	18
National Institutes of Health					Assay Description [3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.				J Biol Chem 283: 10543-9 (2008) Article DOI: 10.1074/jbc.M707463200 BindingDB Entry DOI: 10.7270/Q2CF9NQ6
National Institutes of Health					More data for this Ligand-Target Pair
Serine/threonine-protein kinase MRCK beta (Homo sapiens (Human))	BDBM50015677 ((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester \| 1,...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	6.96E+3	-6.87	n/a	n/a	n/a	n/a	n/a	7.4	18
National Institutes of Health					Assay Description [3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.				J Biol Chem 283: 10543-9 (2008) Article DOI: 10.1074/jbc.M707463200 BindingDB Entry DOI: 10.7270/Q2CF9NQ6
National Institutes of Health					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM50015677 ((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester \| 1,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	5.24E+3	n/a	n/a	n/a	n/a
University of Houston Curated by ChEMBL					Assay Description Binding affinity to GST-tagged PKCtheta expressed in Escherichia coli BL21(DE3) by fluorescence quenching				Bioorg Med Chem 18: 1591-8 (2010) Article DOI: 10.1016/j.bmc.2009.12.075 BindingDB Entry DOI: 10.7270/Q2KP834V
University of Houston Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM50015677 ((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester \| 1,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.62E+4	n/a	n/a	n/a	n/a
University of Houston Curated by ChEMBL					Assay Description Binding affinity to GST-tagged PKCdelta expressed in Escherichia coli BL21(DE3) by fluorescence quenching				Bioorg Med Chem 18: 1591-8 (2010) Article DOI: 10.1016/j.bmc.2009.12.075 BindingDB Entry DOI: 10.7270/Q2KP834V
University of Houston Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C, epsilon (Homo sapiens (Human))	BDBM50015677 ((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester \| 1,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	8.19E+3	n/a	n/a	n/a	n/a
University of Houston Curated by ChEMBL					Assay Description Binding affinity to GST-tagged PKCepsilon expressed in Escherichia coli BL21(DE3) by fluorescence quenching				Bioorg Med Chem 18: 1591-8 (2010) Article DOI: 10.1016/j.bmc.2009.12.075 BindingDB Entry DOI: 10.7270/Q2KP834V
University of Houston Curated by ChEMBL					More data for this Ligand-Target Pair