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SMILES: Cc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1

InChI Key: InChIKey=DDHMZMZQNLXNGY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50016165   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A (Homo sapiens (Human))	BDBM50016165 (CHEMBL3261516) Show SMILES Cc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1 Show InChI InChI=1S/C15H12ClN5OS/c1-7-2-3-8(9(16)6-7)11-12(13(17)22)23-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay				Eur J Med Chem 80: 364-82 (2014) Article DOI: 10.1016/j.ejmech.2014.04.013 BindingDB Entry DOI: 10.7270/Q2NC62R8
					More data for this Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A (Homo sapiens (Human))	BDBM50016165 (CHEMBL3261516) Show SMILES Cc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1 Show InChI InChI=1S/C15H12ClN5OS/c1-7-2-3-8(9(16)6-7)11-12(13(17)22)23-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs				Eur J Med Chem 80: 364-82 (2014) Article DOI: 10.1016/j.ejmech.2014.04.013 BindingDB Entry DOI: 10.7270/Q2NC62R8
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM50016165 (CHEMBL3261516) Show SMILES Cc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1 Show InChI InChI=1S/C15H12ClN5OS/c1-7-2-3-8(9(16)6-7)11-12(13(17)22)23-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay				Eur J Med Chem 80: 364-82 (2014) Article DOI: 10.1016/j.ejmech.2014.04.013 BindingDB Entry DOI: 10.7270/Q2NC62R8
					More data for this Ligand-Target Pair