BDBM50016477 CHEMBL3265102

SMILES: COc1cccc(\C=C2\C(=O)Nc3cc(Cl)ccc23)c1-c1ccc(cc1)C#N

InChI Key: InChIKey=WYGDOPWLZDQSDU-YBFXNURJSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50016477   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50016477 (CHEMBL3265102) Show SMILES COc1cccc(\C=C2\C(=O)Nc3cc(Cl)ccc23)c1-c1ccc(cc1)C#N Show InChI InChI=1S/C23H15ClN2O2/c1-28-21-4-2-3-16(22(21)15-7-5-14(13-25)6-8-15)11-19-18-10-9-17(24)12-20(18)26-23(19)27/h2-12H,1H3,(H,26,27)/b19-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Medical Science and Peking Union Medical College Curated by ChEMBL					Assay Description Binding affinity to MDM2 (1 to 118) (unknown origin) after 30 mins by fluorescence polarization assay				Eur J Med Chem 81: 277-88 (2014) Article DOI: 10.1016/j.ejmech.2014.05.027 BindingDB Entry DOI: 10.7270/Q2736SGW
					More data for this Ligand-Target Pair