BDBM50016909 CHEMBL140417::Methyl-[2-(naphthalen-1-yloxy)-ethyl]-propyl-amine
SMILES: CCCN(C)CCOc1cccc2ccccc12
InChI Key: InChIKey=NNOQKMUYNWQAJH-UHFFFAOYSA-N
Data: 5 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50016909 (CHEMBL140417 | Methyl-[2-(naphthalen-1-yloxy)-ethy...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand. | J Med Chem 32: 859-63 (1989) BindingDB Entry DOI: 10.7270/Q2571CMK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1D (Homo sapiens (Human)) | BDBM50016909 (CHEMBL140417 | Methyl-[2-(naphthalen-1-yloxy)-ethy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 103 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical College of Virginia/Virginia Commonwealth University Curated by ChEMBL | Assay Description Compound was tested for its agonist activity against human recombinant 5-hydroxytryptamine 1D receptor alpha for comparison purpose. | J Med Chem 40: 4415-9 (1998) Article DOI: 10.1021/jm970507t BindingDB Entry DOI: 10.7270/Q2Z038TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1B (Homo sapiens (Human)) | BDBM50016909 (CHEMBL140417 | Methyl-[2-(naphthalen-1-yloxy)-ethy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 750 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical College of Virginia/Virginia Commonwealth University Curated by ChEMBL | Assay Description Agonist activity to the human recombinant 5-hydroxytryptamine 1B receptor | J Med Chem 40: 4415-9 (1998) Article DOI: 10.1021/jm970507t BindingDB Entry DOI: 10.7270/Q2Z038TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 1B/1D receptor (Rattus norvegicus (Rat)) | BDBM50016909 (CHEMBL140417 | Methyl-[2-(naphthalen-1-yloxy)-ethy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand. | J Med Chem 32: 859-63 (1989) BindingDB Entry DOI: 10.7270/Q2571CMK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor beta (Rattus norvegicus (Rat)) | BDBM50016909 (CHEMBL140417 | Methyl-[2-(naphthalen-1-yloxy)-ethy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibitory activity against beta adrenergic receptor of rat frontal cortex homogenate using (1.0 nM) [3H]- dihydroalprenolol | J Med Chem 32: 859-63 (1989) BindingDB Entry DOI: 10.7270/Q2571CMK | |||||||||||
More data for this Ligand-Target Pair |