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BDBM50016972 4-Piperazin-1-yl-furo[3,2-c]pyridine; hydrochloride::CHEMBL543969::CHEMBL595555

SMILES: C1CN(CCN1)c1nccc2occc12

InChI Key: InChIKey=LUIZVTKJWSGSPA-UHFFFAOYSA-N

Data: 1 KI  5 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50016972   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50016972
PNG
(4-Piperazin-1-yl-furo[3,2-c]pyridine; hydrochlorid...)
Show SMILES C1CN(CCN1)c1nccc2occc12
Show InChI InChI=1S/C11H13N3O/c1-3-13-11(9-2-8-15-10(1)9)14-6-4-12-5-7-14/h1-3,8,12H,4-7H2
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PC cid
PC sid
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Article
PubMed
22n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT


Bioorg Med Chem Lett 20: 266-71 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.112
BindingDB Entry DOI: 10.7270/Q2154H5M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50016972
PNG
(4-Piperazin-1-yl-furo[3,2-c]pyridine; hydrochlorid...)
Show SMILES C1CN(CCN1)c1nccc2occc12
Show InChI InChI=1S/C11H13N3O/c1-3-13-11(9-2-8-15-10(1)9)14-6-4-12-5-7-14/h1-3,8,12H,4-7H2
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n/an/an/an/a 164n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity against human 5HT2C receptor by FLIPR assay


Bioorg Med Chem Lett 20: 266-71 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.112
BindingDB Entry DOI: 10.7270/Q2154H5M
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50016972
PNG
(4-Piperazin-1-yl-furo[3,2-c]pyridine; hydrochlorid...)
Show SMILES C1CN(CCN1)c1nccc2occc12
Show InChI InChI=1S/C11H13N3O/c1-3-13-11(9-2-8-15-10(1)9)14-6-4-12-5-7-14/h1-3,8,12H,4-7H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
Ability to bind at Dopamine receptor D2 of rat corpus striatum by displacing [3H]spiperone


J Med Chem 32: 1147-56 (1989)


BindingDB Entry DOI: 10.7270/Q2HD7W8D
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50016972
PNG
(4-Piperazin-1-yl-furo[3,2-c]pyridine; hydrochlorid...)
Show SMILES C1CN(CCN1)c1nccc2occc12
Show InChI InChI=1S/C11H13N3O/c1-3-13-11(9-2-8-15-10(1)9)14-6-4-12-5-7-14/h1-3,8,12H,4-7H2
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PC cid
PC sid
UniChem
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n/an/a 426n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL




J Med Chem 32: 1147-56 (1989)


BindingDB Entry DOI: 10.7270/Q2HD7W8D
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50016972
PNG
(4-Piperazin-1-yl-furo[3,2-c]pyridine; hydrochlorid...)
Show SMILES C1CN(CCN1)c1nccc2occc12
Show InChI InChI=1S/C11H13N3O/c1-3-13-11(9-2-8-15-10(1)9)14-6-4-12-5-7-14/h1-3,8,12H,4-7H2
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n/an/a 144n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL




J Med Chem 32: 1147-56 (1989)


BindingDB Entry DOI: 10.7270/Q2HD7W8D
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)
BDBM50016972
PNG
(4-Piperazin-1-yl-furo[3,2-c]pyridine; hydrochlorid...)
Show SMILES C1CN(CCN1)c1nccc2occc12
Show InChI InChI=1S/C11H13N3O/c1-3-13-11(9-2-8-15-10(1)9)14-6-4-12-5-7-14/h1-3,8,12H,4-7H2
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 150n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL




J Med Chem 32: 1147-56 (1989)


BindingDB Entry DOI: 10.7270/Q2HD7W8D
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50016972
PNG
(4-Piperazin-1-yl-furo[3,2-c]pyridine; hydrochlorid...)
Show SMILES C1CN(CCN1)c1nccc2occc12
Show InChI InChI=1S/C11H13N3O/c1-3-13-11(9-2-8-15-10(1)9)14-6-4-12-5-7-14/h1-3,8,12H,4-7H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
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CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 377n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro inhibition of arachidonic acid induced platelet aggregation in human platelet-rich plasma


J Med Chem 32: 1147-56 (1989)


BindingDB Entry DOI: 10.7270/Q2HD7W8D
More data for this
Ligand-Target Pair