BDBM50017117 4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-butyric acid ethyl ester::CHEMBL288553

SMILES: CCOC(=O)CCCOc1cc(ccc1OC)C1CNC(=O)C1

InChI Key: InChIKey=IYKCJPHQRHPCQS-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50017117   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 5A (Bos taurus)	BDBM50017117 (4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-bu...) Show SMILES CCOC(=O)CCCOc1cc(ccc1OC)C1CNC(=O)C1 Show InChI InChI=1S/C17H23NO5/c1-3-22-17(20)5-4-8-23-15-9-12(6-7-14(15)21-2)13-10-16(19)18-11-13/h6-7,9,13H,3-5,8,10-11H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50017117 (4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-bu...) Show SMILES CCOC(=O)CCCOc1cc(ccc1OC)C1CNC(=O)C1 Show InChI InChI=1S/C17H23NO5/c1-3-22-17(20)5-4-8-23-15-9-12(6-7-14(15)21-2)13-10-16(19)18-11-13/h6-7,9,13H,3-5,8,10-11H2,1-2H3,(H,18,19)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Bos taurus-BOVINE)	BDBM50017117 (4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-bu...) Show SMILES CCOC(=O)CCCOc1cc(ccc1OC)C1CNC(=O)C1 Show InChI InChI=1S/C17H23NO5/c1-3-22-17(20)5-4-8-23-15-9-12(6-7-14(15)21-2)13-10-16(19)18-11-13/h6-7,9,13H,3-5,8,10-11H2,1-2H3,(H,18,19)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair