BDBM50017279 CHEMBL3287703::US10099993, Compound 52

SMILES: COc1cc(ccc1OCCCCOc1ccc(C(C)=O)c(O)c1C)C(O)=O

InChI Key: InChIKey=GVGMDPZYUHZPRH-UHFFFAOYSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50017279   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017279 (CHEMBL3287703 | US10099993, Compound 52) Show SMILES COc1cc(ccc1OCCCCOc1ccc(C(C)=O)c(O)c1C)C(O)=O Show InChI InChI=1S/C21H24O7/c1-13-17(9-7-16(14(2)22)20(13)23)27-10-4-5-11-28-18-8-6-15(21(24)25)12-19(18)26-3/h6-9,12,23H,4-5,10-11H2,1-3H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	161	n/a	n/a	n/a	n/a
Sanford-Burnham Medical Research Institute Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...				J Med Chem 57: 4154-72 (2014) Article DOI: 10.1021/jm5000563 BindingDB Entry DOI: 10.7270/Q2GH9KH9
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50017279 (CHEMBL3287703 | US10099993, Compound 52) Show SMILES COc1cc(ccc1OCCCCOc1ccc(C(C)=O)c(O)c1C)C(O)=O Show InChI InChI=1S/C21H24O7/c1-13-17(9-7-16(14(2)22)20(13)23)27-10-4-5-11-28-18-8-6-15(21(24)25)12-19(18)26-3/h6-9,12,23H,4-5,10-11H2,1-3H3,(H,24,25)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE US Patent									US Patent US10099993 (2018) BindingDB Entry DOI: 10.7270/Q2Z89FFP
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017279 (CHEMBL3287703 | US10099993, Compound 52) Show SMILES COc1cc(ccc1OCCCCOc1ccc(C(C)=O)c(O)c1C)C(O)=O Show InChI InChI=1S/C21H24O7/c1-13-17(9-7-16(14(2)22)20(13)23)27-10-4-5-11-28-18-8-6-15(21(24)25)12-19(18)26-3/h6-9,12,23H,4-5,10-11H2,1-3H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	161	n/a	n/a	7.3	25
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10099993 (2018) BindingDB Entry DOI: 10.7270/Q2Z89FFP
					More data for this Ligand-Target Pair