BDBM50017421 CHEMBL3288290
SMILES: NCCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2s1)NC(=O)N1CCC(CC1)n1c(=O)[nH]c2ccccc2c1=O)C(=O)N1CCN(CC1)c1ccncc1
InChI Key: InChIKey=FDBAKQVBPQKPKG-SZAHLOSFSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human)) | BDBM50017421 (CHEMBL3288290) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmuno... | Bioorg Med Chem Lett 24: 2744-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.033 BindingDB Entry DOI: 10.7270/Q2Q241S2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human)) | BDBM50017421 (CHEMBL3288290) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Displacement of [125I]-hCGRP from CGRP receptor in human SK-N-MC cell membranes after 2 hrs by scintillation counting analysis | Bioorg Med Chem Lett 24: 2744-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.033 BindingDB Entry DOI: 10.7270/Q2Q241S2 | |||||||||||
More data for this Ligand-Target Pair |