BDBM50017437 1,1-Dioxo-2-[4-(2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-yl)-butyl]-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one; dihydrochloride::CHEMBL3217071::CHEMBL543248
SMILES: Cl.Cl.O=C1N(CCCCN2CCN(CC2)c2cnccn2)S(=O)(=O)c2ccccc12
InChI Key: InChIKey=YCSBEGYVFULTIZ-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50017437 (1,1-Dioxo-2-[4-(2,3,5,6-tetrahydro-[1,2']bipyrazin...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Curated by ChEMBL | Assay Description In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus and value ranges from 6 - 13 | J Med Chem 32: 1024-33 (1989) BindingDB Entry DOI: 10.7270/Q21G0MVD | |||||||||||
More data for this Ligand-Target Pair |