BDBM50017961 CHEMBL3289346

SMILES: CCOC(=O)C1=C([C@@H](NC(=O)N1)c1ccc(o1)-c1cccc(c1)C(F)(F)F)C(=O)c1ccc(OC)cc1

InChI Key: InChIKey=ZUSCSFYLDYUECT-NRFANRHFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50017961   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50017961 (CHEMBL3289346) Show SMILES CCOC(=O)C1=C([C@@H](NC(=O)N1)c1ccc(o1)-c1cccc(c1)C(F)(F)F)C(=O)c1ccc(OC)cc1 |r,t:5| Show InChI InChI=1S/C26H21F3N2O6/c1-3-36-24(33)22-20(23(32)14-7-9-17(35-2)10-8-14)21(30-25(34)31-22)19-12-11-18(37-19)15-5-4-6-16(13-15)26(27,28)29/h4-13,21H,3H2,1-2H3,(H2,30,31,34)/t21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Salerno Curated by ChEMBL					Assay Description Inhibition of mPGES-1 in interleukin-1 beta-stimulated human A549 cell microsomes assessed as reduction in PGE2 production using PGH2 as substrate tr...				Eur J Med Chem 80: 407-15 (2014) Article DOI: 10.1016/j.ejmech.2014.04.061 BindingDB Entry DOI: 10.7270/Q28S4RGX
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