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BDBM50018001 CHEMBL3289659

SMILES: C/C(/C=C/C=C(/C)\C=C1/CCCc2ccc(C)cc12)=C\C(O)=O

InChI Key: InChIKey=TZMKYYXLMOFFMM-NDMWHMLYSA-N

Data: 2 Kd 2 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50018001
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Retinoic acid receptor RXR-alpha (Homo sapiens (Human))	BDBM50018001 (CHEMBL3289659) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.86E+3	n/a	n/a	n/a	n/a	n/a
University of Alabama at Birmingham Curated by ChEMBL					Assay Description Agonist activity at human RXR-alpha-ligand binding domain homodimers assessed as coactivator recruitment by measuring GRIP1 binding to receptor by is...				J Med Chem 57: 5370-80 (2014) Article DOI: 10.1021/jm5004792 BindingDB Entry DOI: 10.7270/Q2183821
University of Alabama at Birmingham Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NR2B Channel Blocker (RAT)	BDBM50018001 (CHEMBL3289659) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
University of Alabama at Birmingham Curated by ChEMBL					Assay Description Agonist activity at RXR-alpha in rat R3KE cells infected with oncogene KLF4-ER assessed as inhibition of KLF4-mediated oncogenic transformation				J Med Chem 57: 5370-80 (2014) Article DOI: 10.1021/jm5004792 BindingDB Entry DOI: 10.7270/Q2183821
University of Alabama at Birmingham Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Retinoic acid receptor RXR-alpha (Homo sapiens (Human))	BDBM50018001 (CHEMBL3289659) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	160	n/a	n/a	n/a	n/a
University of Alabama at Birmingham Curated by ChEMBL					Assay Description Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after ...				J Med Chem 57: 5370-80 (2014) Article DOI: 10.1021/jm5004792 BindingDB Entry DOI: 10.7270/Q2183821
University of Alabama at Birmingham Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Retinoic acid receptor RXR-alpha (Homo sapiens (Human))	BDBM50018001 (CHEMBL3289659) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a
University of Alabama at Birmingham Curated by ChEMBL					Assay Description Binding affinity to human RXR-alpha-ligand binding domain homodimers by fluorescence quenching method				J Med Chem 57: 5370-80 (2014) Article DOI: 10.1021/jm5004792 BindingDB Entry DOI: 10.7270/Q2183821
University of Alabama at Birmingham Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)