Found 5 hits for monomerid = 50018265 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50018265
(CHEMBL3290293)Show SMILES Cn1cc(cn1)-c1ccc2ncc3n(C)c(=O)n(-c4ccc(cc4)C(C)(C)C#N)c3c2c1 Show InChI InChI=1S/C25H22N6O/c1-25(2,15-26)18-6-8-19(9-7-18)31-23-20-11-16(17-12-28-29(3)14-17)5-10-21(20)27-13-22(23)30(4)24(31)32/h5-14H,1-4H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant mTOR assessed as inhibition of 4EBP1 phosphorylation after 30 mins by TR-FRET analysis |
J Med Chem 57: 4834-48 (2014)
Article DOI: 10.1021/jm500361r BindingDB Entry DOI: 10.7270/Q2CJ8G1T |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50018265
(CHEMBL3290293)Show SMILES Cn1cc(cn1)-c1ccc2ncc3n(C)c(=O)n(-c4ccc(cc4)C(C)(C)C#N)c3c2c1 Show InChI InChI=1S/C25H22N6O/c1-25(2,15-26)18-6-8-19(9-7-18)31-23-20-11-16(17-12-28-29(3)14-17)5-10-21(20)27-13-22(23)30(4)24(31)32/h5-14H,1-4H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University
Curated by ChEMBL
| Assay Description Inhibition of human PI3K-alpha assessed as inhibition of Ptdlns(3,4,5)P3 phosphorylation after 1 hr by TR-FRET analysis |
J Med Chem 57: 4834-48 (2014)
Article DOI: 10.1021/jm500361r BindingDB Entry DOI: 10.7270/Q2CJ8G1T |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50018265
(CHEMBL3290293)Show SMILES Cn1cc(cn1)-c1ccc2ncc3n(C)c(=O)n(-c4ccc(cc4)C(C)(C)C#N)c3c2c1 Show InChI InChI=1S/C25H22N6O/c1-25(2,15-26)18-6-8-19(9-7-18)31-23-20-11-16(17-12-28-29(3)14-17)5-10-21(20)27-13-22(23)30(4)24(31)32/h5-14H,1-4H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University
Curated by ChEMBL
| Assay Description Inhibition of human PI3K-delta assessed as inhibition of Ptdlns(3,4,5)P3 phosphorylation after 1 hr by TR-FRET analysis |
J Med Chem 57: 4834-48 (2014)
Article DOI: 10.1021/jm500361r BindingDB Entry DOI: 10.7270/Q2CJ8G1T |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50018265
(CHEMBL3290293)Show SMILES Cn1cc(cn1)-c1ccc2ncc3n(C)c(=O)n(-c4ccc(cc4)C(C)(C)C#N)c3c2c1 Show InChI InChI=1S/C25H22N6O/c1-25(2,15-26)18-6-8-19(9-7-18)31-23-20-11-16(17-12-28-29(3)14-17)5-10-21(20)27-13-22(23)30(4)24(31)32/h5-14H,1-4H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University
Curated by ChEMBL
| Assay Description Inhibition of human PI3K-gamma assessed as inhibition of Ptdlns(3,4,5)P3 phosphorylation after 1 hr by TR-FRET analysis |
J Med Chem 57: 4834-48 (2014)
Article DOI: 10.1021/jm500361r BindingDB Entry DOI: 10.7270/Q2CJ8G1T |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50018265
(CHEMBL3290293)Show SMILES Cn1cc(cn1)-c1ccc2ncc3n(C)c(=O)n(-c4ccc(cc4)C(C)(C)C#N)c3c2c1 Show InChI InChI=1S/C25H22N6O/c1-25(2,15-26)18-6-8-19(9-7-18)31-23-20-11-16(17-12-28-29(3)14-17)5-10-21(20)27-13-22(23)30(4)24(31)32/h5-14H,1-4H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University
Curated by ChEMBL
| Assay Description Inhibition of human PI3K-beta assessed as inhibition of Ptdlns(3,4,5)P3 phosphorylation after 1 hr by TR-FRET analysis |
J Med Chem 57: 4834-48 (2014)
Article DOI: 10.1021/jm500361r BindingDB Entry DOI: 10.7270/Q2CJ8G1T |
More data for this Ligand-Target Pair | |