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BDBM50018315 2-Ethynyl-3',4'-dimethoxy-biphenyl-4-carboxylic acid (1-methyl-4-pyridin-3-yl-butyl)-amide::CHEMBL430969

SMILES: COc1ccc(cc1OC)-c1ccc(cc1C#C)C(=O)N[C@H](C)CCCc1cccnc1

InChI Key: InChIKey=ALHVSDKNZPMBLQ-LJQANCHMSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50018315   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50018315
PNG
(2-Ethynyl-3',4'-dimethoxy-biphenyl-4-carboxylic ac...)
Show SMILES COc1ccc(cc1OC)-c1ccc(cc1C#C)C(=O)N[C@H](C)CCCc1cccnc1
Show InChI InChI=1S/C27H28N2O3/c1-5-21-16-23(11-13-24(21)22-12-14-25(31-3)26(17-22)32-4)27(30)29-19(2)8-6-9-20-10-7-15-28-18-20/h1,7,10-19H,6,8-9H2,2-4H3,(H,29,30)/t19-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]-PAF as radioligand.


J Med Chem 32: 1814-20 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ8ZCJ
More data for this
Ligand-Target Pair