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BDBM50018372 5-Cyclohexyl-5-(4-methoxy-phenyl)-penta-2,4-dienoic acid (1-methyl-4-pyridin-3-yl-butyl)-amide::CHEMBL416124

SMILES: COc1ccc(cc1)C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)\C1CCCCC1

InChI Key: InChIKey=ZDHBRXKWSOVSKM-HUVLGCKISA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50018372   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50018372
PNG
(5-Cyclohexyl-5-(4-methoxy-phenyl)-penta-2,4-dienoi...)
Show SMILES COc1ccc(cc1)C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)\C1CCCCC1
Show InChI InChI=1S/C28H36N2O2/c1-22(9-6-10-23-11-8-20-29-21-23)30-28(31)15-7-14-27(24-12-4-3-5-13-24)25-16-18-26(32-2)19-17-25/h7-8,11,14-22,24H,3-6,9-10,12-13H2,1-2H3,(H,30,31)/b15-7+,27-14+/t22-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]-PAF as radioligand


J Med Chem 32: 1820-35 (1989)


BindingDB Entry DOI: 10.7270/Q2NZ86MR
More data for this
Ligand-Target Pair