BDBM50018547 CHEMBL3290678

SMILES: CCOc1cc(ccc1CN1C(C(C(=O)c2ccccc2)=C(N[C@H](C)c2ccccc2)C1=O)c1ccc(Br)cc1)C(F)(F)F

InChI Key: InChIKey=LMPJGYWUFPAMMB-GFTAOQHMSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50018547   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50018547 (CHEMBL3290678) Show SMILES CCOc1cc(ccc1CN1C(C(C(=O)c2ccccc2)=C(N[C@H](C)c2ccccc2)C1=O)c1ccc(Br)cc1)C(F)(F)F |r,t:22| Show InChI InChI=1S/C35H30BrF3N2O3/c1-3-44-29-20-27(35(37,38)39)17-14-26(29)21-41-32(24-15-18-28(36)19-16-24)30(33(42)25-12-8-5-9-13-25)31(34(41)43)40-22(2)23-10-6-4-7-11-23/h4-20,22,32,40H,3,21H2,1-2H3/t22-,32?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.02E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Second Military Medical University Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay				Bioorg Med Chem Lett 24: 2648-50 (2014) Article DOI: 10.1016/j.bmcl.2014.04.063 BindingDB Entry DOI: 10.7270/Q2QV3P22
					More data for this Ligand-Target Pair