BDBM50019059 (+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol::3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol::3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol(2-FEPI)::CHEMBL43711
SMILES: CNCC(O)c1ccc(O)c(O)c1F
InChI Key: InChIKey=HGZKLMFEVVYGMO-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Adrenergic receptor alpha-2 (Homo sapiens (Human)) | BDBM50019059 ((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes Curated by ChEMBL | Assay Description Binding affinity against alpha-2 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidine | J Med Chem 31: 1972-7 (1988) BindingDB Entry DOI: 10.7270/Q2V69K54 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50019059 ((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Displacement of [3H]clonidine from adrenergic alpha 2 receptor of rat cerebral cortical membranes | J Med Chem 36: 3947-55 (1994) BindingDB Entry DOI: 10.7270/Q2QC044C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (Canis familiaris) | BDBM50019059 ((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Binding of [3H]-dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranes | J Med Chem 43: 1611-9 (2000) BindingDB Entry DOI: 10.7270/Q25M64ZV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-1 adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50019059 ((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Binding of [3H]-dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes | J Med Chem 43: 1611-9 (2000) BindingDB Entry DOI: 10.7270/Q25M64ZV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-1 adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50019059 ((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Displacement of [3H]dihydroalprenolol from adrenergic beta 1 receptor of rat cerebral cortical membranes | J Med Chem 36: 3947-55 (1994) BindingDB Entry DOI: 10.7270/Q2QC044C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-1 adrenergic receptor (GUINEA PIG) | BDBM50019059 ((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes Curated by ChEMBL | Assay Description Binding affinity against beta-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of Dihydro-[3H]-alprenolol | J Med Chem 31: 1972-7 (1988) BindingDB Entry DOI: 10.7270/Q2V69K54 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50019059 ((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.65E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Displacement of [3H]WB-4101 from adrenergic alpha 1 receptor of rat cerebral cortical membranes | J Med Chem 36: 3947-55 (1994) BindingDB Entry DOI: 10.7270/Q2QC044C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50019059 ((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.65E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes Curated by ChEMBL | Assay Description Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101 | J Med Chem 31: 1972-7 (1988) BindingDB Entry DOI: 10.7270/Q2V69K54 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor beta (Rattus norvegicus (Rat)) | BDBM50019059 ((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Stimulation of cyclic AMP accumulation in C6 glioma cells expressing adrenergic beta receptor | J Med Chem 36: 3947-55 (1994) BindingDB Entry DOI: 10.7270/Q2QC044C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-1 adrenergic receptor (GUINEA PIG) | BDBM50019059 ((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
National Institute of Diabetes Curated by ChEMBL | Assay Description Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria | J Med Chem 31: 1972-7 (1988) BindingDB Entry DOI: 10.7270/Q2V69K54 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor beta (Rattus norvegicus (Rat)) | BDBM50019059 ((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
National Institute of Diabetes Curated by ChEMBL | Assay Description Agonistic potency at beta adrenergic receptor for the stimulation of accumulation of cyclic AMP in cultured C6 glioma cells | J Med Chem 31: 1972-7 (1988) BindingDB Entry DOI: 10.7270/Q2V69K54 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor alpha-2 (Homo sapiens (Human)) | BDBM50019059 ((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a |
National Institute of Diabetes Curated by ChEMBL | Assay Description Agonistic potency at alpha 2-Adrenergic receptor for inhibition of 10 uM forskolin-elicited stimulation of adenylate cyclase in human platelet membra... | J Med Chem 31: 1972-7 (1988) BindingDB Entry DOI: 10.7270/Q2V69K54 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50019059 ((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a |
National Institute of Diabetes Curated by ChEMBL | Assay Description Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pi... | J Med Chem 31: 1972-7 (1988) BindingDB Entry DOI: 10.7270/Q2V69K54 | |||||||||||
More data for this Ligand-Target Pair |