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BDBM50019061 (+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol::4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol::4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol(6-FNE)::CHEMBL281232
SMILES: NCC(O)c1cc(O)c(O)cc1F
InChI Key: InChIKey=SBUQBFTXTZSRMH-UHFFFAOYSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adrenergic receptor alpha-2 (Homo sapiens (Human)) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes Curated by ChEMBL | Assay Description Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101 | J Med Chem 31: 1972-7 (1988) BindingDB Entry DOI: 10.7270/Q2V69K54 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand | J Med Chem 28: 1398-404 (1985) BindingDB Entry DOI: 10.7270/Q2H41TM1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Displacement of [3H]clonidine from adrenergic alpha 2 receptor of rat cerebral cortical membranes | J Med Chem 36: 3947-55 (1994) BindingDB Entry DOI: 10.7270/Q2QC044C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity against alpha-1 adrenergic receptor in rat using [3H]prazosin as radioligand | J Med Chem 28: 1398-404 (1985) BindingDB Entry DOI: 10.7270/Q2H41TM1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Displacement of [3H]WB-4101 from adrenergic alpha 1 receptor of rat cerebral cortical membranes | J Med Chem 36: 3947-55 (1994) BindingDB Entry DOI: 10.7270/Q2QC044C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes Curated by ChEMBL | Assay Description Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101 | J Med Chem 31: 1972-7 (1988) BindingDB Entry DOI: 10.7270/Q2V69K54 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic receptor (GUINEA PIG) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes Curated by ChEMBL | Assay Description Binding affinity against beta-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of Dihydro-[3H]-alprenolol | J Med Chem 31: 1972-7 (1988) BindingDB Entry DOI: 10.7270/Q2V69K54 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Rattus norvegicus) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Binding affinity against adrenergic beta 2 receptor versus 1 nM [3H]dihydroalprenolol in rat cerebral cerebellar membranes | J Med Chem 36: 3947-55 (1994) BindingDB Entry DOI: 10.7270/Q2QC044C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 4.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Displacement of [3H]dihydroalprenolol from adrenergic beta 1 receptor of rat cerebral cortical membranes | J Med Chem 36: 3947-55 (1994) BindingDB Entry DOI: 10.7270/Q2QC044C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-2 adrenergic receptor (Canis familiaris) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 5.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Binding of [3H]-dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranes | J Med Chem 43: 1611-9 (2000) BindingDB Entry DOI: 10.7270/Q25M64ZV | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 6.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Binding of [3H]-dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes | J Med Chem 43: 1611-9 (2000) BindingDB Entry DOI: 10.7270/Q25M64ZV | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor alpha (Rattus norvegicus (rat)-Rattus norvegicus (Rat)-RA...) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro... | J Med Chem 22: 1493-7 (1979) Article DOI: 10.1021/jm00198a012 BindingDB Entry DOI: 10.7270/Q2RV0RQK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor beta (Rattus norvegicus (Rat)) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Agonist activity at beta-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectros... | J Med Chem 22: 1493-7 (1979) Article DOI: 10.1021/jm00198a012 BindingDB Entry DOI: 10.7270/Q2RV0RQK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor alpha (Rattus norvegicus (rat)-Rattus norvegicus (Rat)-RA...) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membrane | J Med Chem 22: 1493-7 (1979) Article DOI: 10.1021/jm00198a012 BindingDB Entry DOI: 10.7270/Q2RV0RQK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-1 adrenergic receptor (GUINEA PIG) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a |
National Institute of Diabetes Curated by ChEMBL | Assay Description Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparations | J Med Chem 31: 1972-7 (1988) BindingDB Entry DOI: 10.7270/Q2V69K54 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor beta (Rattus norvegicus (Rat)) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Displacement of [3H]dihydroalprenolol from beta-adrenergic receptor in Sprague-Dawley rat cerebral cortical membrane | J Med Chem 22: 1493-7 (1979) Article DOI: 10.1021/jm00198a012 BindingDB Entry DOI: 10.7270/Q2RV0RQK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 1.25E+5 | n/a | n/a | n/a | n/a |
National Institute of Diabetes Curated by ChEMBL | Assay Description Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pi... | J Med Chem 31: 1972-7 (1988) BindingDB Entry DOI: 10.7270/Q2V69K54 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor beta (Rattus norvegicus (Rat)) | BDBM50019061 ((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Stimulation of cyclic AMP accumulation in C6 glioma cells expressing adrenergic beta receptor | J Med Chem 36: 3947-55 (1994) BindingDB Entry DOI: 10.7270/Q2QC044C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
