BDBM50019115 CHEMBL3288410

SMILES: Cc1nc(CCc2nc3cc(C)ccc3n2-c2ccccc2)n2cccnc12

InChI Key: InChIKey=VOYXDWSUNQJWTO-UHFFFAOYSA-N

Data: 1 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50019115   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50019115 (CHEMBL3288410) Show SMILES Cc1nc(CCc2nc3cc(C)ccc3n2-c2ccccc2)n2cccnc12 Show InChI InChI=1S/C23H21N5/c1-16-9-10-20-19(15-16)26-22(28(20)18-7-4-3-5-8-18)12-11-21-25-17(2)23-24-13-6-14-27(21)23/h3-10,13-15H,11-12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Yamanouchi Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...				Bioorg Med Chem 22: 3515-26 (2014) Article DOI: 10.1016/j.bmc.2014.04.023 BindingDB Entry DOI: 10.7270/Q2RN39D7
					More data for this Ligand-Target Pair				3D Structure (crystal)