BindingDB PrimarySearch

BDBM50019213 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one::5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::CHEMBL452::CLONAZEPAM

SMILES: [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1

InChI Key: InChIKey=DGBIGWXXNGSACT-UHFFFAOYSA-N

Data: 23 KI 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50019213
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Gamma-aminobutyric acid type B receptor subunit 1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	PubMed	0.75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 1154-60 (1991) BindingDB Entry DOI: 10.7270/Q2125R4D
Georgetown University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 1154-60 (1991) BindingDB Entry DOI: 10.7270/Q2125R4D
Georgetown University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 1154-60 (1991) BindingDB Entry DOI: 10.7270/Q2125R4D
Georgetown University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 1154-60 (1991) BindingDB Entry DOI: 10.7270/Q2125R4D
Georgetown University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens (Human))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	1.27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universität Heidelberg Curated by PDSP K_i Database									Science 245: 1389-92 (1989) Article DOI: 10.1126/science.2551039 BindingDB Entry DOI: 10.7270/Q2C53JCF
Universität Heidelberg Curated by PDSP K_i Database					More data for this Ligand-Target Pair
GABA A Alpha2Beta1Gamma2 (Homo sapiens (Human))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universität Heidelberg Curated by PDSP K_i Database									Science 245: 1389-92 (1989) Article DOI: 10.1126/science.2551039 BindingDB Entry DOI: 10.7270/Q2C53JCF
Universität Heidelberg Curated by PDSP K_i Database					More data for this Ligand-Target Pair
GABA A receptor alpha-3/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universität Heidelberg Curated by PDSP K_i Database									Science 245: 1389-92 (1989) Article DOI: 10.1126/science.2551039 BindingDB Entry DOI: 10.7270/Q2C53JCF
Universität Heidelberg Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research Foundation Curated by PDSP K_i Database									Psychopharmacology (Berl) 124: 57-73 (1996) Article DOI: 10.1007/bf02245606 BindingDB Entry DOI: 10.7270/Q2610XV6
Janssen Research Foundation Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	18.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Dental College Curated by PDSP K_i Database									Biochem Pharmacol 55: 209-14 (1998) Article DOI: 10.1016/s0006-2952(97)00433-4 BindingDB Entry DOI: 10.7270/Q2NP22ZJ
Tokyo Dental College Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by PDSP K_i Database									J Pharmacol Exp Ther 279: 803-12 (1996) BindingDB Entry DOI: 10.7270/Q29P305P
Leiden University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	33.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Dental College Curated by PDSP K_i Database									Biochem Pharmacol 55: 209-14 (1998) Article DOI: 10.1016/s0006-2952(97)00433-4 BindingDB Entry DOI: 10.7270/Q2NP22ZJ
Tokyo Dental College Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 1154-60 (1991) BindingDB Entry DOI: 10.7270/Q2125R4D
Georgetown University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Proc Natl Acad Sci U S A 74: 3805-9 (1977) Article DOI: 10.1073/pnas.74.9.3805 BindingDB Entry DOI: 10.7270/Q2Q23XR0
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	5.08E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Proc Natl Acad Sci U S A 74: 3805-9 (1977) Article DOI: 10.1073/pnas.74.9.3805 BindingDB Entry DOI: 10.7270/Q2Q23XR0
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Proc Natl Acad Sci U S A 74: 3805-9 (1977) Article DOI: 10.1073/pnas.74.9.3805 BindingDB Entry DOI: 10.7270/Q2Q23XR0
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Dental College Curated by PDSP K_i Database									Biochem Pharmacol 55: 209-14 (1998) Article DOI: 10.1016/s0006-2952(97)00433-4 BindingDB Entry DOI: 10.7270/Q2NP22ZJ
Tokyo Dental College Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Dental College Curated by PDSP K_i Database									Biochem Pharmacol 55: 209-14 (1998) Article DOI: 10.1016/s0006-2952(97)00433-4 BindingDB Entry DOI: 10.7270/Q2NP22ZJ
Tokyo Dental College Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Technion-Israel Institute of Technology Curated by PDSP K_i Database									Life Sci 49: 1155-61 (1991) Article DOI: 10.1016/0024-3205(91)90562-p BindingDB Entry DOI: 10.7270/Q2319TC5
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Technion-Israel Institute of Technology Curated by PDSP K_i Database									Life Sci 49: 1155-61 (1991) Article DOI: 10.1016/0024-3205(91)90562-p BindingDB Entry DOI: 10.7270/Q2319TC5
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Technion-Israel Institute of Technology Curated by PDSP K_i Database									Life Sci 49: 1155-61 (1991) Article DOI: 10.1016/0024-3205(91)90562-p BindingDB Entry DOI: 10.7270/Q2319TC5
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Technion-Israel Institute of Technology Curated by PDSP K_i Database									Life Sci 49: 1155-61 (1991) Article DOI: 10.1016/0024-3205(91)90562-p BindingDB Entry DOI: 10.7270/Q2319TC5
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens (Human))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Technion-Israel Institute of Technology Curated by PDSP K_i Database									Life Sci 49: 1155-61 (1991) Article DOI: 10.1016/0024-3205(91)90562-p BindingDB Entry DOI: 10.7270/Q2319TC5
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens (Human))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Technion-Israel Institute of Technology Curated by PDSP K_i Database									Life Sci 49: 1155-61 (1991) Article DOI: 10.1016/0024-3205(91)90562-p BindingDB Entry DOI: 10.7270/Q2319TC5
					More data for this Ligand-Target Pair
Cholecystokinin A receptor (Cavia porcellus)	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Half-maximal inhibition of [125I]CCK-33 binding to guinea pig brain(cortex) cholecystokinin receptor				J Med Chem 30: 1229-39 (1987) BindingDB Entry DOI: 10.7270/Q2SF2WS2
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Cholecystokinin receptor (RAT)	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp& Dohme Research Laboratories Curated by ChEMBL					Assay Description Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissue				J Med Chem 31: 2235-46 (1989) BindingDB Entry DOI: 10.7270/Q2PG1S9K
Merck Sharp& Dohme Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Homo sapiens (Human))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	1.80E+9	n/a	n/a	n/a	n/a	n/a	n/a
Harvard University Curated by ChEMBL					Assay Description Binding affinity of compound towards Benzodiazepine receptor in a competition assay				J Med Chem 39: 5246-56 (1997) Article DOI: 10.1021/jm960536o BindingDB Entry DOI: 10.7270/Q2NG4RTQ
Harvard University Curated by ChEMBL					More data for this Ligand-Target Pair
Cholecystokinin receptor (RAT)	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Half-maximal inhibition of [125I]-CCK-33 binding to rat pancreas cholecystokinin receptor				J Med Chem 30: 1229-39 (1987) BindingDB Entry DOI: 10.7270/Q2SF2WS2
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Cholecystokinin receptor (Homo sapiens (Human))	BDBM50019213 (1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp& Dohme Research Laboratories Curated by ChEMBL					Assay Description Half-maximal inhibition of [125I]-CCK-8(+) binding to cholecystokinin receptor from guinea pig brain tissue				J Med Chem 31: 2235-46 (1989) BindingDB Entry DOI: 10.7270/Q2PG1S9K
Merck Sharp& Dohme Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair