Found 2 hits for monomerid = 50019410 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neurotensin receptor 2
(Rattus norvegicus) | BDBM50019410
(CHEMBL3290094)Show SMILES CCc1c(nn(c1-c1c(OC)cccc1OC)-c1ccnc2cc(Cl)ccc12)C(=O)N[C@@H](C1CCCCC1)C(O)=O |r,wU:31.35,(24.97,-8.62,;24.81,-10.16,;23.41,-10.78,;22.07,-10.01,;20.93,-11.04,;21.56,-12.45,;23.09,-12.29,;24.43,-13.78,;23.95,-15.24,;22.44,-15.56,;21.97,-17.03,;24.98,-16.39,;26.49,-16.06,;26.96,-14.6,;25.93,-13.46,;26.41,-11.99,;27.91,-11.67,;20.55,-14.18,;21.32,-15.52,;20.55,-16.85,;19.01,-16.85,;18.24,-15.52,;16.7,-15.52,;15.93,-14.18,;14.39,-14.18,;16.7,-12.85,;18.24,-12.85,;19.01,-14.18,;21.91,-8.48,;23.16,-7.58,;20.51,-7.85,;20.34,-6.32,;18.94,-5.7,;17.69,-6.6,;16.28,-5.97,;16.12,-4.44,;17.37,-3.54,;18.78,-4.16,;21.59,-5.42,;21.43,-3.89,;23,-6.04,)| Show InChI InChI=1S/C31H33ClN4O5/c1-4-20-28(30(37)34-27(31(38)39)18-9-6-5-7-10-18)35-36(23-15-16-33-22-17-19(32)13-14-21(22)23)29(20)26-24(40-2)11-8-12-25(26)41-3/h8,11-18,27H,4-7,9-10H2,1-3H3,(H,34,37)(H,38,39)/t27-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma counting |
J Med Chem 57: 5318-32 (2014)
Article DOI: 10.1021/jm5003843
BindingDB Entry DOI: 10.7270/Q2PR7XJD |
More data for this
Ligand-Target Pair | |
Neurotensin receptor 2
(Rattus norvegicus) | BDBM50019410
(CHEMBL3290094)Show SMILES CCc1c(nn(c1-c1c(OC)cccc1OC)-c1ccnc2cc(Cl)ccc12)C(=O)N[C@@H](C1CCCCC1)C(O)=O |r,wU:31.35,(24.97,-8.62,;24.81,-10.16,;23.41,-10.78,;22.07,-10.01,;20.93,-11.04,;21.56,-12.45,;23.09,-12.29,;24.43,-13.78,;23.95,-15.24,;22.44,-15.56,;21.97,-17.03,;24.98,-16.39,;26.49,-16.06,;26.96,-14.6,;25.93,-13.46,;26.41,-11.99,;27.91,-11.67,;20.55,-14.18,;21.32,-15.52,;20.55,-16.85,;19.01,-16.85,;18.24,-15.52,;16.7,-15.52,;15.93,-14.18,;14.39,-14.18,;16.7,-12.85,;18.24,-12.85,;19.01,-14.18,;21.91,-8.48,;23.16,-7.58,;20.51,-7.85,;20.34,-6.32,;18.94,-5.7,;17.69,-6.6,;16.28,-5.97,;16.12,-4.44,;17.37,-3.54,;18.78,-4.16,;21.59,-5.42,;21.43,-3.89,;23,-6.04,)| Show InChI InChI=1S/C31H33ClN4O5/c1-4-20-28(30(37)34-27(31(38)39)18-9-6-5-7-10-18)35-36(23-15-16-33-22-17-19(32)13-14-21(22)23)29(20)26-24(40-2)11-8-12-25(26)41-3/h8,11-18,27H,4-7,9-10H2,1-3H3,(H,34,37)(H,38,39)/t27-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 94 | n/a | n/a | n/a | n/a |
Research Triangle Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay |
J Med Chem 57: 5318-32 (2014)
Article DOI: 10.1021/jm5003843
BindingDB Entry DOI: 10.7270/Q2PR7XJD |
More data for this
Ligand-Target Pair | |
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