BDBM50019901 CHEMBL3287206::US9533999, i-34
SMILES: CC(C)c1nc2N(Cc3ccc(F)c(OC(F)(F)F)c3)C(=O)CS(=O)(=O)c2s1
InChI Key: InChIKey=ZWDRWONPTSZBKW-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Intermediate conductance calcium-activated potassium channel protein 4 (Homo sapiens (Human)) | BDBM50019901 (CHEMBL3287206 | US9533999, i-34) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ... | US Patent US9533999 (2017) BindingDB Entry DOI: 10.7270/Q21V5C4S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Intermediate conductance calcium-activated potassium channel protein 4 (Homo sapiens (Human)) | BDBM50019901 (CHEMBL3287206 | US9533999, i-34) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition... | ACS Med Chem Lett 5: 460-1 (2014) Article DOI: 10.1021/ml500090s BindingDB Entry DOI: 10.7270/Q2RJ4M2T | |||||||||||
More data for this Ligand-Target Pair |