BDBM50019959 1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butan-1-one::1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butan-1-one(fluanisone)::CHEMBL58792::Fluanisone
SMILES: COc1ccccc1N1CCN(CCCC(=O)c2ccc(F)cc2)CC1
InChI Key: InChIKey=IRYFCWPNDIUQOW-UHFFFAOYSA-N
Data: 12 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50019959 (1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.870 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duphar Research Laboratories Curated by ChEMBL | Assay Description Ability to inhibit [3H]WB-4101 binding to alpha-1 adrenergic receptor was determined in rat | J Med Chem 30: 2099-104 (1987) BindingDB Entry DOI: 10.7270/Q2W959R8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50019959 (1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.870 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duphar Research Laboratories Curated by ChEMBL | Assay Description Potency to displace [3H]- WB-4101 from alpha-1 adrenergic receptor in rat striatum | J Med Chem 31: 1934-40 (1988) BindingDB Entry DOI: 10.7270/Q2SJ1JMB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50019959 (1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Solvay Pharma Curated by ChEMBL | Assay Description Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si... | J Med Chem 40: 300-12 (1997) Article DOI: 10.1021/jm960496o BindingDB Entry DOI: 10.7270/Q27W6B96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50019959 (1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duphar Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum | J Med Chem 31: 1934-40 (1988) BindingDB Entry DOI: 10.7270/Q2SJ1JMB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50019959 (1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duphar Research Laboratories Curated by ChEMBL | Assay Description Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in rat | J Med Chem 30: 2099-104 (1987) BindingDB Entry DOI: 10.7270/Q2W959R8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50019959 (1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Solvay Pharma Curated by ChEMBL | Assay Description In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum. | J Med Chem 40: 300-12 (1997) Article DOI: 10.1021/jm960496o BindingDB Entry DOI: 10.7270/Q27W6B96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (BOVINE) | BDBM50019959 (1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by PDSP Ki Database | Mol Pharmacol 12: 800-12 (1976) BindingDB Entry DOI: 10.7270/Q22B8WH6 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (BOVINE) | BDBM50019959 (1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by PDSP Ki Database | J Neuropsychiatry Clin Neurosci 8: 223-6 (1996) Article DOI: 10.1176/jnp.8.2.223 BindingDB Entry DOI: 10.7270/Q27S7M9V | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50019959 (1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duphar Research Laboratories Curated by ChEMBL | Assay Description Ability to inhibit [3H]spiperone binding to 5-hydroxytryptamine 2 receptor determined in rat | J Med Chem 30: 2099-104 (1987) BindingDB Entry DOI: 10.7270/Q2W959R8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50019959 (1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duphar Research Laboratories Curated by ChEMBL | Assay Description Potency to displace [3H]- Spiperone from 5-hydroxytryptamine 2 receptor in rat striatum | J Med Chem 31: 1934-40 (1988) BindingDB Entry DOI: 10.7270/Q2SJ1JMB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DRD1 (BOVINE) | BDBM50019959 (1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by PDSP Ki Database | J Neuropsychiatry Clin Neurosci 8: 223-6 (1996) Article DOI: 10.1176/jnp.8.2.223 BindingDB Entry DOI: 10.7270/Q27S7M9V | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DRD1 (BOVINE) | BDBM50019959 (1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by PDSP Ki Database | Mol Pharmacol 12: 800-12 (1976) BindingDB Entry DOI: 10.7270/Q22B8WH6 | ||||||||||||
More data for this Ligand-Target Pair |