BDBM50020169 CHEMBL3288506::US9914707, I-9

SMILES: CCc1cccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1

InChI Key: InChIKey=WPVPVCZYFQZIDO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50020169   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020169 (CHEMBL3288506 | US9914707, I-9) Show SMILES CCc1cccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C26H22N4O/c1-2-16-6-3-8-19(14-16)28-26(31)22-10-4-7-17-15-18(12-13-20(17)22)21-9-5-11-23-24(21)25(27)30-29-23/h3-15H,2H2,1H3,(H,28,31)(H3,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020169 (CHEMBL3288506 | US9914707, I-9) Show SMILES CCc1cccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C26H22N4O/c1-2-16-6-3-8-19(14-16)28-26(31)22-10-4-7-17-15-18(12-13-20(17)22)21-9-5-11-23-24(21)25(27)30-29-23/h3-15H,2H2,1H3,(H,28,31)(H3,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18.2	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...				J Med Chem 51: 725-36 (2008) BindingDB Entry DOI: 10.7270/Q2DR2XS5
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020169 (CHEMBL3288506 | US9914707, I-9) Show SMILES CCc1cccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C26H22N4O/c1-2-16-6-3-8-19(14-16)28-26(31)22-10-4-7-17-15-18(12-13-20(17)22)21-9-5-11-23-24(21)25(27)30-29-23/h3-15H,2H2,1H3,(H,28,31)(H3,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair