BDBM50020225 CHEMBL3288523::US9914707, I-27

SMILES: Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)NC3CC3)c12

InChI Key: InChIKey=QXOCJYVEXQVZSL-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50020225   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020225 (CHEMBL3288523 | US9914707, I-27) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)NC3CC3)c12 Show InChI InChI=1S/C21H18N4O/c22-20-19-16(4-2-6-18(19)24-25-20)13-7-10-15-12(11-13)3-1-5-17(15)21(26)23-14-8-9-14/h1-7,10-11,14H,8-9H2,(H,23,26)(H3,22,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020225 (CHEMBL3288523 | US9914707, I-27) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)NC3CC3)c12 Show InChI InChI=1S/C21H18N4O/c22-20-19-16(4-2-6-18(19)24-25-20)13-7-10-15-12(11-13)3-1-5-17(15)21(26)23-14-8-9-14/h1-7,10-11,14H,8-9H2,(H,23,26)(H3,22,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	95.2	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...				J Med Chem 51: 725-36 (2008) BindingDB Entry DOI: 10.7270/Q2DR2XS5
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020225 (CHEMBL3288523 | US9914707, I-27) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)NC3CC3)c12 Show InChI InChI=1S/C21H18N4O/c22-20-19-16(4-2-6-18(19)24-25-20)13-7-10-15-12(11-13)3-1-5-17(15)21(26)23-14-8-9-14/h1-7,10-11,14H,8-9H2,(H,23,26)(H3,22,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair