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SMILES: Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccnc3)c12

InChI Key: InChIKey=KVERPNKQBHWWHW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50020246   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020246 (CHEMBL3288521 | US9914707, I-25) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccnc3)c12 Show InChI InChI=1S/C23H17N5O/c24-22-21-18(6-2-8-20(21)27-28-22)15-9-10-17-14(12-15)4-1-7-19(17)23(29)26-16-5-3-11-25-13-16/h1-13H,(H,26,29)(H3,24,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20.2	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...				J Med Chem 51: 725-36 (2008) BindingDB Entry DOI: 10.7270/Q2DR2XS5
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020246 (CHEMBL3288521 | US9914707, I-25) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccnc3)c12 Show InChI InChI=1S/C23H17N5O/c24-22-21-18(6-2-8-20(21)27-28-22)15-9-10-17-14(12-15)4-1-7-19(17)23(29)26-16-5-3-11-25-13-16/h1-13H,(H,26,29)(H3,24,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair