null

SMILES: [#6]-[#8]-c1cc(\[#6]=[#6]\[#6](=O)\[#6]=[#6]\c2cc(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c(-[#8]-[#6])c2)cc(-[#6]\[#6]=[#6](/[#6])-[#6])c1-[#8]

InChI Key: InChIKey=AGFUAPYONOPZQE-UTLPMFLDSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50020565   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50020565 (CHEMBL2392188) Show SMILES [#6]-[#8]-c1cc(\[#6]=[#6]\[#6](=O)\[#6]=[#6]\c2cc(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c(-[#8]-[#6])c2)cc(-[#6]\[#6]=[#6](/[#6])-[#6])c1-[#8] Show InChI InChI=1S/C29H34O5/c1-19(2)7-11-23-15-21(17-26(33-5)28(23)31)9-13-25(30)14-10-22-16-24(12-8-20(3)4)29(32)27(18-22)34-6/h7-10,13-18,31-32H,11-12H2,1-6H3/b13-9+,14-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University Jena Curated by ChEMBL					Assay Description Inhibition of mPGES1-mediated PGE2 production in microsomes of IL-1beta stimulated human A549 cells preincubated for 15 mins by RP-HPLC analysis				J Med Chem 57: 5638-48 (2014) Article DOI: 10.1021/jm500308c BindingDB Entry DOI: 10.7270/Q2HT2QWN
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50020565 (CHEMBL2392188) Show SMILES [#6]-[#8]-c1cc(\[#6]=[#6]\[#6](=O)\[#6]=[#6]\c2cc(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c(-[#8]-[#6])c2)cc(-[#6]\[#6]=[#6](/[#6])-[#6])c1-[#8] Show InChI InChI=1S/C29H34O5/c1-19(2)7-11-23-15-21(17-26(33-5)28(23)31)9-13-25(30)14-10-22-16-24(12-8-20(3)4)29(32)27(18-22)34-6/h7-10,13-18,31-32H,11-12H2,1-6H3/b13-9+,14-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
University Jena Curated by ChEMBL					Assay Description Inhibition of human recombinant 5-LO expressed in Escherichia coli Bl21 (DE3) using arachidonic acid as substrate preincubated for 10 mins measured a...				J Med Chem 57: 5638-48 (2014) Article DOI: 10.1021/jm500308c BindingDB Entry DOI: 10.7270/Q2HT2QWN
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50020565 (CHEMBL2392188) Show SMILES [#6]-[#8]-c1cc(\[#6]=[#6]\[#6](=O)\[#6]=[#6]\c2cc(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c(-[#8]-[#6])c2)cc(-[#6]\[#6]=[#6](/[#6])-[#6])c1-[#8] Show InChI InChI=1S/C29H34O5/c1-19(2)7-11-23-15-21(17-26(33-5)28(23)31)9-13-25(30)14-10-22-16-24(12-8-20(3)4)29(32)27(18-22)34-6/h7-10,13-18,31-32H,11-12H2,1-6H3/b13-9+,14-10+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
University Jena Curated by ChEMBL					Assay Description Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assay				J Med Chem 57: 5638-48 (2014) Article DOI: 10.1021/jm500308c BindingDB Entry DOI: 10.7270/Q2HT2QWN
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50020565 (CHEMBL2392188) Show SMILES [#6]-[#8]-c1cc(\[#6]=[#6]\[#6](=O)\[#6]=[#6]\c2cc(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c(-[#8]-[#6])c2)cc(-[#6]\[#6]=[#6](/[#6])-[#6])c1-[#8] Show InChI InChI=1S/C29H34O5/c1-19(2)7-11-23-15-21(17-26(33-5)28(23)31)9-13-25(30)14-10-22-16-24(12-8-20(3)4)29(32)27(18-22)34-6/h7-10,13-18,31-32H,11-12H2,1-6H3/b13-9+,14-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University Jena Curated by ChEMBL					Assay Description Inhibition of 5-LO in human neutrophils using arachidonic acid as substrate preincubated for 15 mins measured after 10 mins by HPLC analysis				J Med Chem 57: 5638-48 (2014) Article DOI: 10.1021/jm500308c BindingDB Entry DOI: 10.7270/Q2HT2QWN
					More data for this Ligand-Target Pair