Found 3 hits for monomerid = 50021714 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021714
(CHEMBL3298418)Show SMILES C[C@@H](NC(=O)N1CCc2cnc(Nc3ccnc(C)c3)nc2C1)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C22H22Cl2N6O/c1-13-9-17(5-7-25-13)28-21-26-11-16-6-8-30(12-20(16)29-21)22(31)27-14(2)15-3-4-18(23)19(24)10-15/h3-5,7,9-11,14H,6,8,12H2,1-2H3,(H,27,31)(H,25,26,28,29)/t14-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description Inhibition of ERK2 in human HepG2 cells assessed as P90RSK phosphorylation at Ser380 after 1.5 hrs by fluorescence assay |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068 BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021714
(CHEMBL3298418)Show SMILES C[C@@H](NC(=O)N1CCc2cnc(Nc3ccnc(C)c3)nc2C1)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C22H22Cl2N6O/c1-13-9-17(5-7-25-13)28-21-26-11-16-6-8-30(12-20(16)29-21)22(31)27-14(2)15-3-4-18(23)19(24)10-15/h3-5,7,9-11,14H,6,8,12H2,1-2H3,(H,27,31)(H,25,26,28,29)/t14-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068 BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50021714
(CHEMBL3298418)Show SMILES C[C@@H](NC(=O)N1CCc2cnc(Nc3ccnc(C)c3)nc2C1)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C22H22Cl2N6O/c1-13-9-17(5-7-25-13)28-21-26-11-16-6-8-30(12-20(16)29-21)22(31)27-14(2)15-3-4-18(23)19(24)10-15/h3-5,7,9-11,14H,6,8,12H2,1-2H3,(H,27,31)(H,25,26,28,29)/t14-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description Inhibition of Cdk2 (unknown origin) |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068 BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this Ligand-Target Pair | |