null
SMILES: OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O
InChI Key: InChIKey=HZZVJAQRINQKSD-PBFISZAISA-N
PDB links: 6 PDB IDs match this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lek d.d. Curated by ChEMBL | Assay Description The compound was tested for its inhibitory activity towards Class A TEM-1 beta-lactamase from Escherichia coli at 0.3 umol | Bioorg Med Chem Lett 12: 971-5 (2002) BindingDB Entry DOI: 10.7270/Q2NC61S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Enterobacter cloacae) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Lek d.d. Curated by ChEMBL | Assay Description The compound was tested for its inhibitory activity towards Class C beta-lactamase from Enterobacter cloacae 908R at 0.8 umol concentration | Bioorg Med Chem Lett 12: 971-5 (2002) BindingDB Entry DOI: 10.7270/Q2NC61S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Citrobacter gillenii) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
H�pital de Bic�tre Curated by ChEMBL | Assay Description Inhibition of Citrobacter gillenii CIP 106783 Beta-lactamase GIL1 expressed in Escherichia coli DH10B | Antimicrob Agents Chemother 51: 1365-72 (2007) Article DOI: 10.1128/AAC.01152-06 BindingDB Entry DOI: 10.7270/Q2S46SS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Lek Pharmaceuticals d.d. Curated by ChEMBL | Assay Description Inhibition of Escherichia coli TEM1 | J Med Chem 50: 4113-21 (2007) Article DOI: 10.1021/jm0703237 BindingDB Entry DOI: 10.7270/Q2FF3T5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase SHV-1 (Klebsiella pneumoniae (Enterobacteria)) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Lek Pharmaceuticals d.d. Curated by ChEMBL | Assay Description Inhibition of Escherichia coli SHV1 | J Med Chem 50: 4113-21 (2007) Article DOI: 10.1021/jm0703237 BindingDB Entry DOI: 10.7270/Q2FF3T5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Enterobacter cloacae) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.36E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Lek Pharmaceuticals d.d. Curated by ChEMBL | Assay Description Inhibition of Enterobacter cloacae AmpC | J Med Chem 50: 4113-21 (2007) Article DOI: 10.1021/jm0703237 BindingDB Entry DOI: 10.7270/Q2FF3T5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Class A beta-lactamase BCL-1 (Bacillus clausii) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
H�pital de Bic�tre Curated by ChEMBL | Assay Description Inhibition of Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) | Antimicrob Agents Chemother 51: 4009-14 (2007) Article DOI: 10.1128/AAC.00537-07 BindingDB Entry DOI: 10.7270/Q20R9QBS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Pasteur Hellenique Curated by ChEMBL | Assay Description Inhibition of Escherichia coli beta-lactamase SCO1 | Antimicrob Agents Chemother 51: 2185-8 (2007) Article DOI: 10.1128/AAC.01439-06 BindingDB Entry DOI: 10.7270/Q2028SFP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Pasteur Hellenique Curated by ChEMBL | Assay Description Inhibition of Escherichia coli K12 TEM1 | Antimicrob Agents Chemother 51: 2185-8 (2007) Article DOI: 10.1128/AAC.01439-06 BindingDB Entry DOI: 10.7270/Q2028SFP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | <4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibitory concentration which is required to cause 50% inhibition of human leukocyte elastase (HLE) enzyme | J Med Chem 33: 2513-21 (1990) BindingDB Entry DOI: 10.7270/Q2Q81C2Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase SHV-1 (Klebsiella pneumoniae (Enterobacteria)) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 20.1 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Escherichia coli HA208 Class-III SHV-1 type beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase BRO-1 (Moraxella catarrhalis) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 30.1 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Branhamella catarrhalis 89001 Class-III BRO-1 type beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Enterobacter cloacae) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Enterobacter cloacae HC8 Class-I beta-lactamase enzyme type P99 | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Proteus mirabilis) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 65.3 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Proteus vulgaris HJ33C Class-I beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Citrobacter freundii) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Citrobacter freundii 87470 Class-I beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase OXA-1 (Escherichia coli (Enterobacteria)) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 401 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Escherichia coli HA209 Class-V OXA-1 type beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Klebsiella oxytoca) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 30.1 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Klebsiella oxytoca HC7 Class-IV K1 type beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 40.2 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Escherichia coli HA58R Class-III TEM-1 type beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Staphylococcus aureus) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank | n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibitory activity against Staphylococcus aureus CJ8 beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metallo-beta-lactamase type 2 (Bacteroides fragilis) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against Bacteroides fragilis 88854 Class-I beta-lactamase enzyme | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Enterobacter cloacae) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against beta-Lactamase enzyme derived from Enterobacter cloacae P99 | Bioorg Med Chem Lett 5: 1513-1518 (1995) Article DOI: 10.1016/0960-894X(95)00249-S BindingDB Entry DOI: 10.7270/Q2ZW1MDG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article | n/a | n/a | 7.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Concentration required for its inhibitory activity against Escherichia coli K12(PSE4) class A beta-lactamase | Citation and Details Article DOI: 10.1016/S0960-894X(01)80506-0 BindingDB Entry DOI: 10.7270/Q21V5HPM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase OXA-1 (Escherichia coli (Enterobacteria)) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article | n/a | n/a | 1.75E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Concentration required for its inhibitory activity against Escherichia coli K12(OXA1) class D beta-lactamase | Citation and Details Article DOI: 10.1016/S0960-894X(01)80506-0 BindingDB Entry DOI: 10.7270/Q21V5HPM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Proteus mirabilis) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article | n/a | n/a | 9.54E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Concentration required for its inhibitory activity against Proteus mirabilis C889 class A beta-lactamase | Citation and Details Article DOI: 10.1016/S0960-894X(01)80506-0 BindingDB Entry DOI: 10.7270/Q21V5HPM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Enterobacter cloacae) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article | n/a | n/a | 8.03E+8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Concentration required for its inhibitory activity against Enterobacter cloacae P99 class C beta-lactamase | Citation and Details Article DOI: 10.1016/S0960-894X(01)80506-0 BindingDB Entry DOI: 10.7270/Q21V5HPM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article | n/a | n/a | 1.45E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Concentration required for its inhibitory activity against Escherichia coli JT4(TEM1) class A beta-lactamase | Citation and Details Article DOI: 10.1016/S0960-894X(01)80506-0 BindingDB Entry DOI: 10.7270/Q21V5HPM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Staphylococcus aureus) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article | n/a | n/a | 1.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Concentration required for its inhibitory activity against Staphylococcus aureus Russel class A beta-lactamase | Citation and Details Article DOI: 10.1016/S0960-894X(01)80506-0 BindingDB Entry DOI: 10.7270/Q21V5HPM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Pseudomonas aeruginosa (PAO1)) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article | n/a | n/a | 2.15E+9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Concentration required for its inhibitory activity against Pseudomonas aeruginosa class C beta-lactamase | Citation and Details Article DOI: 10.1016/S0960-894X(01)80506-0 BindingDB Entry DOI: 10.7270/Q21V5HPM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase TEM (Escherichia coli) | BDBM50021959 (CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 145 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of Escherichia coli JT4 beta-lactamase TEM1 assessed as inhibition of nitrocefin hydrolysis preincubated for 5 mins by microtiter plate as... | J Nat Prod 57: 654-7 (1994) Article DOI: 10.1021/np50107a016 BindingDB Entry DOI: 10.7270/Q2SQ935W | |||||||||||
More data for this Ligand-Target Pair |
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