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BDBM50022051 1-Phenyl-6-chloro-7-hydroxy-N-methyl-1,2,3,4-tetrahydroisoquinoline::6-Chloro-2-methyl-1-phenyl-1,2,3,4-tetrahydro-isoquinolin-7-ol::CHEMBL57579

SMILES: CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1

InChI Key: InChIKey=AVXGCGYACIYZAR-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50022051   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DOPAMINE


(RAT)
BDBM50022051
PNG
(1-Phenyl-6-chloro-7-hydroxy-N-methyl-1,2,3,4-tetra...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1
Show InChI InChI=1S/C16H16ClNO/c1-18-8-7-12-9-14(17)15(19)10-13(12)16(18)11-5-3-2-4-6-11/h2-6,9-10,16,19H,7-8H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
13n/an/an/an/an/an/an/an/a



University of North Carolina

Curated by ChEMBL


Assay Description
Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM


J Med Chem 31: 1941-6 (1988)


BindingDB Entry DOI: 10.7270/Q20002PD
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50022051
PNG
(1-Phenyl-6-chloro-7-hydroxy-N-methyl-1,2,3,4-tetra...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1
Show InChI InChI=1S/C16H16ClNO/c1-18-8-7-12-9-14(17)15(19)10-13(12)16(18)11-5-3-2-4-6-11/h2-6,9-10,16,19H,7-8H2,1H3
Reactome pathway
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
504n/an/an/an/an/an/an/an/a



Universidad de Valencia

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in Wistar rat striatal membrane by liquid scintillation counting


Bioorg Med Chem 17: 4968-80 (2009)


Article DOI: 10.1016/j.bmc.2009.05.079
BindingDB Entry DOI: 10.7270/Q26D5T2B
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50022051
PNG
(1-Phenyl-6-chloro-7-hydroxy-N-methyl-1,2,3,4-tetra...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1
Show InChI InChI=1S/C16H16ClNO/c1-18-8-7-12-9-14(17)15(19)10-13(12)16(18)11-5-3-2-4-6-11/h2-6,9-10,16,19H,7-8H2,1H3
Reactome pathway
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
915n/an/an/an/an/an/an/an/a



University of North Carolina

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 at 0.02 nM


J Med Chem 31: 1941-6 (1988)


BindingDB Entry DOI: 10.7270/Q20002PD
More data for this
Ligand-Target Pair