BDBM50022054 7-Chloro-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol::CHEMBL57988

SMILES: Oc1cc2C(CNCc2cc1Cl)c1ccccc1

InChI Key: InChIKey=MGAQDUSMABIJCH-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50022054   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(1A) dopamine receptor (RAT)	BDBM50022054 (7-Chloro-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-6...) Show SMILES Oc1cc2C(CNCc2cc1Cl)c1ccccc1 Show InChI InChI=1S/C15H14ClNO/c16-14-6-11-8-17-9-13(12(11)7-15(14)18)10-4-2-1-3-5-10/h1-7,13,17-18H,8-9H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	565	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Binding affinity towards dopamine receptor D1 using [3H]-SCH-23,390 was determined in rat striatal membranes				J Med Chem 37: 4317-28 (1995) Checked by Author BindingDB Entry DOI: 10.7270/Q2NC607Q
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50022054 (7-Chloro-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-6...) Show SMILES Oc1cc2C(CNCc2cc1Cl)c1ccccc1 Show InChI InChI=1S/C15H14ClNO/c16-14-6-11-8-17-9-13(12(11)7-15(14)18)10-4-2-1-3-5-10/h1-7,13,17-18H,8-9H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	565	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM				J Med Chem 31: 1941-6 (1988) BindingDB Entry DOI: 10.7270/Q20002PD
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50022054 (7-Chloro-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-6...) Show SMILES Oc1cc2C(CNCc2cc1Cl)c1ccccc1 Show InChI InChI=1S/C15H14ClNO/c16-14-6-11-8-17-9-13(12(11)7-15(14)18)10-4-2-1-3-5-10/h1-7,13,17-18H,8-9H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.62E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of [3H]spiperone binding to Dopamine receptor D2 at 0.02 nM				J Med Chem 31: 1941-6 (1988) BindingDB Entry DOI: 10.7270/Q20002PD
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50022054 (7-Chloro-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-6...) Show SMILES Oc1cc2C(CNCc2cc1Cl)c1ccccc1 Show InChI InChI=1S/C15H14ClNO/c16-14-6-11-8-17-9-13(12(11)7-15(14)18)10-4-2-1-3-5-10/h1-7,13,17-18H,8-9H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.62E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Binding affinity towards dopamine (D1) receptor using [3H]-spiperone was determined in rat striatal membranes				J Med Chem 37: 4317-28 (1995) Checked by Author BindingDB Entry DOI: 10.7270/Q2NC607Q
					More data for this Ligand-Target Pair