BDBM50022163 6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione::CHEMBL54950
SMILES: O=c1cc(Nc2ccc3CCCc3c2)[nH]c(=O)[nH]1
InChI Key: InChIKey=CVUMGFDAIXWWCV-UHFFFAOYSA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase III (Bacillus subtilis) | BDBM50022163 (6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione | CHEM...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Concentration producing 50% inhibition of Bacillus subtilis DNA topoisomerase III in the presence of dGTP using DNA Polymerase assay | J Med Chem 29: 676-81 (1986) BindingDB Entry DOI: 10.7270/Q2MP528D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase III (Bacillus subtilis) | BDBM50022163 (6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione | CHEM...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 420 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition against Bacillus subtilis DNA topoisomerase III (wild type) | J Med Chem 23: 34-8 (1980) BindingDB Entry DOI: 10.7270/Q2125RPK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase III (Bacillus subtilis) | BDBM50022163 (6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione | CHEM...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 420 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition constant against Bacillus subtilis DNA topoisomerase III (wild type). | J Med Chem 27: 181-5 (1984) BindingDB Entry DOI: 10.7270/Q2Q241FK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase III (Bacillus subtilis) | BDBM50022163 (6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione | CHEM...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition constant against Bacillus subtilis azp-12 DNA topoisomerase III (mutant enzyme). | J Med Chem 27: 181-5 (1984) BindingDB Entry DOI: 10.7270/Q2Q241FK | |||||||||||
More data for this Ligand-Target Pair |