BDBM50022184 7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3)::7,8-Dihydroxy-4-methyl-chromen-2-one::7,8-dihydroxy-4-methyl-2H-chromen-2-one::7,8-dihydroxy-4-methylcoumarin::CHEMBL276618

SMILES: Cc1cc(=O)oc2c(O)c(O)ccc12

InChI Key: InChIKey=NWQBYMPNIJXFNQ-UHFFFAOYSA-N

Data: 4 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50022184   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50022184 (7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3) | 7,8-...) Show SMILES Cc1cc(=O)oc2c(O)c(O)ccc12 Show InChI InChI=1S/C10H8O4/c1-5-4-8(12)14-10-6(5)2-3-7(11)9(10)13/h2-4,11,13H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	270	-8.32	n/a	n/a	n/a	n/a	n/a	7.5	4
S.G.S.I.T.S					Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of...				J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human))	BDBM50022184 (7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3) | 7,8-...) Show SMILES Cc1cc(=O)oc2c(O)c(O)ccc12 Show InChI InChI=1S/C10H8O4/c1-5-4-8(12)14-10-6(5)2-3-7(11)9(10)13/h2-4,11,13H,1H3	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		2.11E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 12 (Homo sapiens (Human))	BDBM50022184 (7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3) | 7,8-...) Show SMILES Cc1cc(=O)oc2c(O)c(O)ccc12 Show InChI InChI=1S/C10H8O4/c1-5-4-8(12)14-10-6(5)2-3-7(11)9(10)13/h2-4,11,13H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	6.60E+3	-6.56	n/a	n/a	n/a	n/a	n/a	7.5	4
S.G.S.I.T.S					Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of...				J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50022184 (7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3) | 7,8-...) Show SMILES Cc1cc(=O)oc2c(O)c(O)ccc12 Show InChI InChI=1S/C10H8O4/c1-5-4-8(12)14-10-6(5)2-3-7(11)9(10)13/h2-4,11,13H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	8.70E+3	-6.41	n/a	n/a	n/a	n/a	n/a	7.5	4
S.G.S.I.T.S					Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of...				J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50022184 (7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3) | 7,8-...) Show SMILES Cc1cc(=O)oc2c(O)c(O)ccc12 Show InChI InChI=1S/C10H8O4/c1-5-4-8(12)14-10-6(5)2-3-7(11)9(10)13/h2-4,11,13H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	>2.00E+5	>-4.69	n/a	n/a	n/a	n/a	n/a	7.5	4
S.G.S.I.T.S					Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of...				J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK
					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50022184 (7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3) | 7,8-...) Show SMILES Cc1cc(=O)oc2c(O)c(O)ccc12 Show InChI InChI=1S/C10H8O4/c1-5-4-8(12)14-10-6(5)2-3-7(11)9(10)13/h2-4,11,13H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for inhibitory concentration against rat lens aldose reductase (uncompetitive inhibition type)				J Med Chem 29: 1094-9 (1986) BindingDB Entry DOI: 10.7270/Q20865WC
					More data for this Ligand-Target Pair
Probable maltase-glucoamylase 2 (Homo sapiens)	BDBM50022184 (7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3) | 7,8-...) Show SMILES Cc1cc(=O)oc2c(O)c(O)ccc12 Show InChI InChI=1S/C10H8O4/c1-5-4-8(12)14-10-6(5)2-3-7(11)9(10)13/h2-4,11,13H,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Goa University Curated by ChEMBL					Assay Description Inhibition of alpha-glucosidase (unknown origin) incubated for 20 mins before pNPG substrate addition and measured after 30 mins by UV spectrometry				Bioorg Med Chem 27: 2340-2344 (2019) Article DOI: 10.1016/j.bmc.2018.12.021
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human))	BDBM50022184 (7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3) | 7,8-...) Show SMILES Cc1cc(=O)oc2c(O)c(O)ccc12 Show InChI InChI=1S/C10H8O4/c1-5-4-8(12)14-10-6(5)2-3-7(11)9(10)13/h2-4,11,13H,1H3	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		n/a	n/a	1.12E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair