BDBM50024253 CHEMBL3334887

SMILES: CCOC(=O)c1ccc(cc1)-c1cn(Cc2ccccc2)c2ccccc12

InChI Key: InChIKey=VFHUVLOTZSSZDR-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50024253   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM50024253 (CHEMBL3334887) Show SMILES CCOC(=O)c1ccc(cc1)-c1cn(Cc2ccccc2)c2ccccc12 Show InChI InChI=1S/C24H21NO2/c1-2-27-24(26)20-14-12-19(13-15-20)22-17-25(16-18-8-4-3-5-9-18)23-11-7-6-10-21(22)23/h3-15,17H,2,16H2,1H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture& Forestry University Curated by ChEMBL					Assay Description Antagonist activity at PAR1 in PAR-1-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...				Bioorg Med Chem Lett 24: 4708-13 (2014) Article DOI: 10.1016/j.bmcl.2014.08.021 BindingDB Entry DOI: 10.7270/Q29P336C
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4) (Homo sapiens (Human))	BDBM50024253 (CHEMBL3334887) Show SMILES CCOC(=O)c1ccc(cc1)-c1cn(Cc2ccccc2)c2ccccc12 Show InChI InChI=1S/C24H21NO2/c1-2-27-24(26)20-14-12-19(13-15-20)22-17-25(16-18-8-4-3-5-9-18)23-11-7-6-10-21(22)23/h3-15,17H,2,16H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in human platelets after 10 mins by flow cytometric analysis				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM50024253 (CHEMBL3334887) Show SMILES CCOC(=O)c1ccc(cc1)-c1cn(Cc2ccccc2)c2ccccc12 Show InChI InChI=1S/C24H21NO2/c1-2-27-24(26)20-14-12-19(13-15-20)22-17-25(16-18-8-4-3-5-9-18)23-11-7-6-10-21(22)23/h3-15,17H,2,16H2,1H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture & Forestry University Curated by ChEMBL					Assay Description Inhibition of PAR1 (unknown origin)				J Med Chem 59: 7690-5 (2016) Article DOI: 10.1021/acs.jmedchem.6b00928
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4) (Homo sapiens (Human))	BDBM50024253 (CHEMBL3334887) Show SMILES CCOC(=O)c1ccc(cc1)-c1cn(Cc2ccccc2)c2ccccc12 Show InChI InChI=1S/C24H21NO2/c1-2-27-24(26)20-14-12-19(13-15-20)22-17-25(16-18-8-4-3-5-9-18)23-11-7-6-10-21(22)23/h3-15,17H,2,16H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Northwest Agriculture& Forestry University Curated by ChEMBL					Assay Description Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation a...				Bioorg Med Chem Lett 24: 4708-13 (2014) Article DOI: 10.1016/j.bmcl.2014.08.021 BindingDB Entry DOI: 10.7270/Q29P336C
					More data for this Ligand-Target Pair